syn-3-(4-fluorophenyl)-3-hydroxy-2-methylpropanoic acid

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: syn-3-(4-fluorophenyl)-3-hydroxy-2-methylpropanoic acid
• 英文别名: (2S,3S)-3-(4-fluorophenyl)-3-hydroxy-2-methylpropanoic acid
• 化学式: C₁₀H₁₁FO₃
• 分子量: 198.194
• InChiKey: CICBYKUXSSLZQN-RCOVLWMOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  对氟苯甲醛 、 丙酸 在 B-bromodicyclohexylborane 、 三乙胺 作用下， 以 乙醚 为溶剂， 反应 2.25h， 以72%的产率得到
  参考文献：
  名称：

  anti-Selective enolboration–aldolization of propanoic acid

  摘要：

  A systematic examination of enolboration-aldolization of propanoic acid has led to an efficient synthesis of anti-beta-hydroxy-alpha-methyl carboxylic acids in consistently high yields and diastereoselectivities by using B-bromodicyclohexylborane as the enolization reagent and triethylamine as the base. (C) 2014 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2013.12.048

文献信息

• anti-Selective enolboration–aldolization of propanoic acid
  作者：P. Veeraraghavan Ramachandran、Prem B. Chanda、Barnabas Otoo

  DOI：10.1016/j.tetlet.2013.12.048

  日期：2014.2

  A systematic examination of enolboration-aldolization of propanoic acid has led to an efficient synthesis of anti-beta-hydroxy-alpha-methyl carboxylic acids in consistently high yields and diastereoselectivities by using B-bromodicyclohexylborane as the enolization reagent and triethylamine as the base. (C) 2014 Published by Elsevier Ltd.