3,4-dihydro-2,2-dimethyl-6-chloro-8-carboxy-2H-1-benzopyran

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 3,4-dihydro-2,2-dimethyl-6-chloro-8-carboxy-2H-1-benzopyran
• 英文别名: 6-Chloro-2,2-dimethyl-3,4-dihydrochromene-8-carboxylic acid
• 化学式: C₁₂H₁₃ClO₃
• 分子量: 240.686
• InChiKey: SFWGHOVDCWARGB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,3-二氨基吡啶 、 3,4-dihydro-2,2-dimethyl-6-chloro-8-carboxy-2H-1-benzopyran 、 P2 O5 生成 2-(6-Chloro-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-8-yl)-1H-imidazo[4,5-b]pyridine monohydrochloride
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• [EN] SPIROXAZOLIDINONE COMPOUNDS<br/>[FR] COMPOSÉS SPIROXAZOLIDINONE
  申请人：MERCK SHARP & DOHME

  公开号：WO2012024183A1

  公开（公告）日：2012-02-23

  Substituted spirocyclic amines of structural formula (I) are selective antagonists of the somatostatin subtype receptor 5 (SSTR5) and are useful for the treatment, control or prevention of disorders responsive to antagonism of SSTR5, such as Type 2 diabetes, insulin resistance, lipid disorders, obesity, atherosclerosis, Metabolic Syndrome, depression, and anxiety.

  结构式（I）的螺环胺是生长抑素亚型受体5（SSTR5）的选择性拮抗剂，可用于治疗、控制或预防对SSTR5拮抗敏感的疾病，如2型糖尿病、胰岛素抵抗、脂质紊乱、肥胖、动脉粥样硬化、代谢综合征、抑郁症和焦虑症。
• SPIRO ISOXAZOLINE COMPOUNDS AS SSTR5 ANTAGONISTS
  申请人：Duffy Joseph L.

  公开号：US20130040978A1

  公开（公告）日：2013-02-14

  Substituted spirocyclic amines of structural formula (I) are selective antagonists of the somatostatin subtype receptor 5 (SSTR5) and are useful for the treatment, control or prevention of disorders responsive to antagonism of SSTR5, such as Type 2 diabetes, insulin resistance, lipid disorders, obesity, atherosclerosis, Metabolic Syndrome, depression, and anxiety.

  结构式(I)的取代螺环胺是生长抑素亚型受体5(SSTR5)的选择性拮抗剂，可用于治疗、控制或预防对SSTR5拮抗敏感的疾病，如2型糖尿病、胰岛素抵抗、脂质紊乱、肥胖症、动脉粥样硬化、代谢综合征、抑郁症和焦虑症。
• SPIROXAZOLIDINONE COMPOUNDS
  申请人：Duffy Joseph L.

  公开号：US20130131042A1

  公开（公告）日：2013-05-23

  Substituted spirocyclic amines of structural formula (I) are selective antagonists of the somatostatin subtype receptor 5 (SSTR5) and are useful for the treatment, control or prevention of disorders responsive to antagonism of SSTR5, such as Type 2 diabetes, insulin resistance, lipid disorders, obesity, atherosclerosis, Metabolic Syndrome, depression, and anxiety.

  结构式(I)的取代螺环胺是生长抑素亚型受体5 (SSTR5)的选择性拮抗剂，可用于治疗、控制或预防对SSTR5拮抗有反应的疾病，如2型糖尿病、胰岛素抵抗、脂质紊乱、肥胖症、动脉粥样硬化、代谢综合征、抑郁症和焦虑症。
• BENZOPYRAN, BENZOTHIOPYRAN AND BENZOFURAN DERIVATIVES AS 5-HT4 ANTAGONISTS
  申请人：SMITHKLINE BEECHAM PLC

  公开号：EP0625149A1

  公开（公告）日：1994-11-23
• US4329459A
  申请人：——

  公开号：US4329459A

  公开（公告）日：1982-05-11