diaza-1,4 bicyclo(2.2.2) octane, 2H2O2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: diaza-1,4 bicyclo(2.2.2) octane, 2H2O2
• 英文别名: Dabco-hydrogen peroxide；1,4-diazabicyclo[2.2.2]octane;hydrogen peroxide
• 化学式: C₆H₁₂N₂*2H₂O₂
• 分子量: 180.204
• InChiKey: QQEDQILYDZCRKD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.36
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  46.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  三乙烯二胺 在 双氧水 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以63%的产率得到diaza-1,4 bicyclo(2.2.2) octane, 2H2O2
  参考文献：
  名称：

  BIS(TRIMETHYLSILYL) PEROXIDE (BTMSPO)

  摘要：

  DOI：

  10.15227/orgsyn.074.0084
• 作为试剂：
  描述：

  三丙基氯硅烷 在 diaza-1,4 bicyclo(2.2.2) octane, 2H2O2 作用下， 以 二氯甲烷 为溶剂， 生成 Bis-(tripropylsilyl)-peroxid
  参考文献：
  名称：

  1,4-二氮杂[2.2.2]双环辛烷-过氧化氢络合物作为无水过氧化氢的来源：双（三烷基甲硅烷基）过氧化物的制备

  摘要：

  代替使用1,4-二氮杂双环[2.2.2]辛烷与过氧化氢形成的固体配合物，它可以与三烷基氯硅烷反应生成双（三烷基甲硅烷基）过氧化物，从而避免了储存和处理浓过氧化氢的危险和不便。屈服。

  DOI：

  10.1016/s0022-328x(00)88466-1

文献信息

• Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
  申请人：Gallop A. Mark

  公开号：US20050107334A1

  公开（公告）日：2005-05-19

  The disclosures herein relate generally to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof, methods of making prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, methods of using prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, and pharmaceutical compositions thereof for treating or preventing common diseases and/or disorders such as spasticity and/or acid reflux disease. The disclosures herein also relate to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof which are suitable for oral administration and to sustained release oral dosage forms thereof.

  本文涉及的内容通常与(±)-4-氨基-3-(4-氯苯基)丁酸及其类似物的酰氧基烷基氨基甲酸酯前药、其制药组合物、制备(±)-4-氨基-3-(4-氯苯基)丁酸及其类似物的前药的方法、使用(±)-4-氨基-3-(4-氯苯基)丁酸及其类似物的前药的方法，以及治疗或预防常见疾病和/或疾病，如痉挛和/或酸反流病的制药组合物。本文还涉及适用于口服和口服缓释剂型的(±)-4-氨基-3-(4-氯苯基)丁酸及其类似物的酰氧基烷基氨基甲酸酯前药。
• Methods for synthesis of acyloxyalkyl compounds
  申请人：Bhat Laxminarayan

  公开号：US20050070715A1

  公开（公告）日：2005-03-31

  Disclosed herein are methods for synthesizing 1-(acyloxy)-alkyl prodrug derivatives of drugs through oxidation of 1-acyl-alkyl derivatives of drugs under anhydrous reaction conditions. The methods typically proceed stereospecifically, in high yield, do not require the use of activated intermediates and/or toxic compounds and are readily amenable to scale-up.

  本文公开了一种通过在无水反应条件下氧化药物的1-酰基-烷基衍生物来合成药物的1-(酰氧基)-烷基前药衍生物的方法。该方法通常具有立体选择性，产率高，不需要使用活性中间体和/或有毒化合物，并且容易扩大规模。
• ACYLOXYALKYL CARBAMATE PRODRUGS, METHODS
  申请人：Gallop Mark A.

  公开号：US20090234138A1

  公开（公告）日：2009-09-17

  The disclosures herein relate generally to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof, methods of making prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, methods of using prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, and pharmaceutical compositions thereof for treating or preventing common diseases and/or disorders such as spasticity and/or acid reflux disease. The disclosures herein also relate to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof which are suitable for oral administration and to sustained release oral dosage forms thereof.

  本文披露了关于(±)-4-氨基-3-(4-氯苯基)丁酸及其类似物的酰氧基烷基氨基甲酸酯前药、其制药组合物、制备(±)-4-氨基-3-(4-氯苯基)丁酸及其类似物的前药的方法、使用(±)-4-氨基-3-(4-氯苯基)丁酸及其类似物的前药的方法，以及用于治疗或预防普通疾病和/或紊乱，如痉挛和/或酸反流病的制药组合物。本文还涉及适用于口服的(±)-4-氨基-3-(4-氯苯基)丁酸及其类似物的酰氧基烷基氨基甲酸酯前药以及其持续释放口服剂型。
• ACYLOXYALKYL CARBAMATE PRODRUGS, METHODS OF SYNTHESIS AND USE
  申请人：Gallop A. Mark

  公开号：US20080096960A1

  公开（公告）日：2008-04-24

  The disclosures herein relate generally to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof, methods of making prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, methods of using prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, and pharmaceutical compositions thereof for treating or preventing common diseases and/or disorders such as spasticity and/or acid reflux disease. The disclosures herein also relate to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof which are suitable for oral administration and to sustained release oral dosage forms thereof.

  本文涉及到(±)-4-氨基-3-(4-氯苯基)丁酸和其类似物的酰氧基烷基氨基甲酸酯前药、其制药组合物、制备(±)-4-氨基-3-(4-氯苯基)丁酸和其类似物的前药的方法、使用(±)-4-氨基-3-(4-氯苯基)丁酸和其类似物的前药的方法，以及其制药组合物用于治疗或预防常见疾病和/或疾病，如痉挛和/或酸逆流病。本文还涉及适用于口服的酰氧基烷基氨基甲酸酯前药和其持续释放口服剂型。
• Acyloxyalkyl carbamate prodrugs of tranexamic acid, methods of synthesis and use
  申请人：Zerangue Noa

  公开号：US20070027210A1

  公开（公告）日：2007-02-01

  Acyloxyalkyl carbamate prodrugs of trans-4-(aminomethyl)-cyclohexanecarboxylic acid, pharmaceutical compositions thereof, methods of making prodrugs of trans-4-(aminomethyl)-cyclohexane-carboxylic acid, and methods of using prodrugs of trans-4-(aminomethyl)-cyclohexanecarboxylic acid and pharmaceutical compositions thereof to treat or prevent various diseases or disorders are disclosed. Acyloxyalkyl carbamate prodrugs of trans-4-(aminomethyl)-cyclohexanecarboxylic acid and pharmaceutical compositions thereof suitable for oral and topical administration and for administration using sustained release dosage forms are also disclosed.

  本发明公开了trans-4-(aminomethyl)-环己烷羧酸的酰氧基烷基氨基甲酸酯前药、其制药组合物、制备trans-4-(aminomethyl)-环己烷羧酸酯类前药的方法，以及使用trans-4-(aminomethyl)-环己烷羧酸酯类前药和制药组合物来治疗或预防各种疾病或紊乱的方法。本发明还公开了适用于口服、局部应用以及使用持续释放剂型给药的酰氧基烷基氨基甲酸酯前药和制药组合物。