4-[2-(4-tert-dutylbenzyl)-1-benzofuran-3-yl]morpholine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 4-[2-(4-tert-dutylbenzyl)-1-benzofuran-3-yl]morpholine
• 英文别名: 4-[2-(4-tert-butylbenzyl)-1-benzofuran-3-yl]morpholine；4-(2-(4-(tert-butyl)benzyl)benzofuran-3-yl)morpholine；4-[2-[(4-Tert-butylphenyl)methyl]-1-benzofuran-3-yl]morpholine；4-[2-[(4-tert-butylphenyl)methyl]-1-benzofuran-3-yl]morpholine
• 化学式: C₂₃H₂₇NO₂
• 分子量: 349.473
• InChiKey: IZSVDLAXAQOMQG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  25.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  吗啉 、 4-叔-丁基苯基乙炔 、 水杨醛 在 四丁基溴化铵 、 potassium carbonate 作用下， 反应 1.25h， 以89%的产率得到4-[2-(4-tert-dutylbenzyl)-1-benzofuran-3-yl]morpholine
  参考文献：
  名称：

  A Solvent-Free and One-Pot Strategy for Ecocompatible Synthesis of Substituted­ Benzofurans from Various Salicylaldehydes, Secondary Amines, and Nonactivated Alkynes Catalyzed by Copper(I) Oxide Nanoparticles

  摘要：

  DOI：

  10.1055/s-0034-1378206

文献信息

• A Solvent-Free and One-Pot Strategy for Ecocompatible Synthesis of Substituted­ Benzofurans from Various Salicylaldehydes, Secondary Amines, and Nonactivated Alkynes Catalyzed by Copper(I) Oxide Nanoparticles
  作者：Hashem Sharghi、Pezhman Shiri、Mahdi Aberi

  DOI：10.1055/s-0034-1378206

  日期：——
• CuI‐catalyzed, one‐pot synthesis of 3‐aminobenzofurans in deep eutectic solvents
  作者：Bahareh Abtahi、Hossein Tavakol

  DOI：10.1002/aoc.6433

  日期：2021.12

  An environmentally friendly method is presented here for the synthesis of various benzofuran derivatives using CuI catalyst. In this line, a one‐pot, 3‐component reaction of alkynes, different aldehydes, and amines is employed in choline chloride‐ethylene glycol deep eutectic solvent as an available, cheap, and green media. The employed method includes easy workup and good yields. In this work, 12 different benzofuran derivatives have been prepared in 7 h at 80°C.