连氮霉素B | 106486-76-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 连氮霉素B
• 中文别名: 5-溴-1,3-苯二醇
• 英文名称: Azinomycin B
• 英文别名: [(1S)-2-[[(1E)-1-[(3R,4R,5S)-3-acetyloxy-4-hydroxy-1-azabicyclo[3.1.0]hexan-2-ylidene]-2-[[(Z)-1-hydroxy-3-oxobut-1-en-2-yl]amino]-2-oxoethyl]amino]-1-[(2S)-2-methyloxiran-2-yl]-2-oxoethyl] 3-methoxy-5-methylnaphthalene-1-carboxylate
• CAS: 106486-76-4
• 化学式: C₃₁H₃₃N₃O₁₁
• 分子量: 623.6
• InChiKey: QIKVYJOCQXXRSJ-PKDLRSQSSA-N

物化性质

• 熔点：
  190° (dec)
• 比旋光度：
  D20 +48° (c = 0.48 in CHCl3)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  45
• 可旋转键数：
  12
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  193
• 氢给体数：
  4
• 氢受体数：
  12

文献信息

• High molecular wegiht polymers, devices and method for making and using same
  申请人：East Anthony

  公开号：US20050048121A1

  公开（公告）日：2005-03-03

  Anhydride polymers that release active or activatable agent(s) have pre-selected properties such as molecular weight, flexibility, hardness, adhesiveness, and other valuable properties. The polymers are suitable for use in compositions, formulations, coatings, devices, and the like that benefit from the controlled release of an agent(s) over a period of time. The polymers are prepared by a process involving various alternative and sequential steps that allow the design a priori of products with specific characteristics. The polymers are suitable as delivery systems, either by themselves, as compositions, formulations or devices.

  无水酐聚合物释放活性或可激活的药剂，具有预选特性，如分子量、柔韧性、硬度、粘附性等其他有价值的特性。这些聚合物适用于在一段时间内控制释放药剂的组合物、配方、涂层、设备等，这些产品受益于药剂的控制释放。这些聚合物是通过涉及各种替代和连续步骤的过程制备的，这些步骤允许事先设计具有特定特性的产品。这些聚合物适合作为传递系统，可以单独使用，也可以作为组合物、配方或设备。
• Epoxy-containing poly(ester amides) and method of use
  申请人：Katsarava Ramaz

  公开号：US20080050419A1

  公开（公告）日：2008-02-28

  The invention provides aliphatic epoxy-containing PEA polymer compositions with film-forming properties. The aliphatic epoxy di-acids used in the invention PEA compositions include non-toxic fatty aliphatic epoxy homologs. A second, C-protected L-lysine-based monomer can be introduced into the polymer to provide additional chain flexibility. The invention PEA polymer compositions are useful for delivery of bioactive agents when administered internally or used in the manufacture of implantable medical devices. Biodegradable hydrogels can be made using the invention epoxy-containing PEAs.

  该发明提供了具有成膜性能的脂肪族环氧含有PEA聚合物组成物。该发明中使用的脂肪族环氧二酸包括非毒性脂肪族环氧同系物。第二种基于C-保护的L-赖氨酸单体可以引入到聚合物中以提供额外的链柔性。该发明的PEA聚合物组成物在内部给药时或用于制造可植入医疗器械时，可用于传递生物活性剂。使用该发明的环氧含有PEAs可以制造可生物降解的水凝胶。
• Fast Degrading Polymers
  申请人：Uhrich Kathryn E.

  公开号：US20090035248A1

  公开（公告）日：2009-02-05

  The invention provides polyanhydrides that degrade in less than 60 hours following topical administration to deliver biologically active compounds.

  该发明提供了聚酸酐，通过局部给药在不到60小时内分解，以释放生物活性化合物。
• Compositions and methods for the inhibition of bone growth and resorption
  申请人：Uhrich E. Kathryn

  公开号：US20050249697A1

  公开（公告）日：2005-11-10

  A composition, or article for inhibition of bone growth and resorption comprises an anti-inflammatory agent(s), optionally other agents and carriers, monomer(s), oligomer(s), polymer(s), salt(s), mixtures(s), dispersion(s) and/or blend(s) thereof, which composition, device, or implant upon polymer erosion releases a bone growth and/or bone resorption retarding, reducing or inhibiting amount of the agent(s). The monomers, oligomers and polymers, releasing active or activatable agent(s), have pre-selected properties such as molecular weight, flexibility, hardness, adhesiveness, and other valuable properties. The monomers, oligomers and polymers may be prepared by a process involving various alternative and sequential steps that allow the design a priori of products with specific characteristics. The composition, device, implant or dressing of this patent are suitable for retarding, reducing or inhibiting bone growth or bone resorption, comprising administering or applying to a subject's pre-selected site a bone growth or resorption reducing amount of the agent(s).

  一种用于抑制骨生长和吸收的组合物或文章包括抗炎剂、可选的其他剂和载体、单体、寡聚体、聚合物、盐、混合物、分散剂和/或其混合物，该组合物、装置或植入物在聚合物侵蚀时释放出抑制、减少或抑制骨生长和/或骨吸收的剂量的药物。释放活性或可激活药物的单体、寡聚体和聚合物具有预选的性质，如分子量、柔韧性、硬度、粘附性和其他有价值的性质。可以通过涉及各种可选和连续步骤的过程来制备单体、寡聚体和聚合物，从而允许事先设计具有特定特性的产品。该专利的组合物、装置、植入物或敷料适用于减缓、减少或抑制骨生长或骨吸收，包括向受试者的预选部位施用或应用抑制骨生长或吸收的药物。
• Acyclovir-peptide analogs
  申请人：Mitra K. Ashim

  公开号：US20050043246A1

  公开（公告）日：2005-02-24

  Dipeptide and tripeptide ester derivatives of acyclovir and its analogs are disclosed which are useful to treat herpes virus infections. Also disclosed is a method for preparing a therapeutic agent for targeted delivery to ocular tissue comprising linking the therapeutic agent to one or more groups of the formula —X—Y-Z (n) -R; wherein each X, Y and Z is independently Met, Val, Thr, Tyr, Trp, Ser, Ala or Gly; each R is independently H or an amino-protecting group; and each n is independently 0 or 1.

  本文公开了乙酰环鸟苷及其类似物的二肽和三肽酯衍生物，可用于治疗疱疹病毒感染。同时，还公开了一种制备治疗剂并针对性地传递到眼部组织的方法，包括将治疗剂与一个或多个公式 -X-Y-Z（n）-R的基团连接起来；其中，每个X、Y和Z独立地为Met、Val、Thr、Tyr、Trp、Ser、Ala或Gly；每个R独立地为H或氨基保护基；每个n独立地为0或1。