1-(4-methoxybenzhydryl)-3,4-dimethoxybenzene

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 1-(4-methoxybenzhydryl)-3,4-dimethoxybenzene
• 英文别名: 4-(4-methoxyphenyl)phenylmethylene-1,2-dimethoxybenzene；1,2-Dimethoxy-4-[(4-methoxyphenyl)-phenylmethyl]benzene；1,2-dimethoxy-4-[(4-methoxyphenyl)-phenylmethyl]benzene
• 化学式: C₂₂H₂₂O₃
• 分子量: 334.415
• InChiKey: FNFUXSAJKLLRQE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  邻苯二甲醚 、 3-((4-methoxyphenyl)(phenyl)methyl)pentane-2,4-dione 在 NaHSO₄/SiO₂ 作用下， 以 氯苯 为溶剂， 反应 6.0h， 以94%的产率得到1-(4-methoxybenzhydryl)-3,4-dimethoxybenzene
  参考文献：
  名称：

  Simple Method for sp2–sp3 and sp3–sp3 Carbon–Carbon Bond Activation in 2-Substituted 1,3-Diketones

  摘要：

  Simple and efficient methods were developed for sp(2)-sp(3) and sp(3)-sp(3) C-C bond-activation reactions of 2-substituted 1,3-diketones. 3-Substituted 3-bromopentane-2,4-diones were deacylated in the presence of an aromatic compound and a silica gel supported Bronsted acid containing sulfonic groups. The carbocation formed by cleavage of the sp(3)-sp(3) C-C bond of the dione alkylated the aromatic compound.

  DOI：

  10.1055/s-0034-1378862

文献信息

• Simple Method for sp2–sp3 and sp3–sp3 Carbon–Carbon Bond Activation in 2-Substituted 1,3-Diketones
  作者：Tadashi Aoyama、Mamiko Hayakawa、Sho Kubota、Sumire Ogawa、Erika Nakajima、Emi Mitsuyama、Taku Iwabuchi、Haruki Kaneko、Rina Obara、Toshio Takido、Mitsuo Kodomari、Akihiko Ouchi

  DOI：10.1055/s-0034-1378862

  日期：——

  Simple and efficient methods were developed for sp(2)-sp(3) and sp(3)-sp(3) C-C bond-activation reactions of 2-substituted 1,3-diketones. 3-Substituted 3-bromopentane-2,4-diones were deacylated in the presence of an aromatic compound and a silica gel supported Bronsted acid containing sulfonic groups. The carbocation formed by cleavage of the sp(3)-sp(3) C-C bond of the dione alkylated the aromatic compound.