(+/-)-1-isopentyl-2-methyl-piperidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (+/-)-1-isopentyl-2-methyl-piperidine
• 英文别名: (+/-)-1-Isopentyl-2-methyl-piperidin；2-Methyl-1-(3-methylbutyl)piperidine
• 化学式: C₁₁H₂₃N
• 分子量: 169.31
• InChiKey: OQMURAPMKVQYLN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  碳酸甲丙酯 、 异戊醇 在 镍 作用下， 200.0 ℃ 、4.9 MPa 条件下， 生成 (+/-)-1-isopentyl-2-methyl-piperidine
  参考文献：
  名称：

  Sawa; Inoue, Shionogi Kenkyusho Nenpo, 1954, # 4, p. 411,413

  摘要：

  DOI：

文献信息

• PKM2 modulators and methods for their use
  申请人：Tolero Pharmaceuticals, Inc.

  公开号：US10207996B2

  公开（公告）日：2019-02-19

  Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

  本研究公开了具有 PKM2 激活剂活性的化合物。这些化合物具有以下结构 (I)： 其中 R1、R2、R3、R4、R5 和 R6 如本文所定义。此外，还公开了与制备和使用此类化合物相关的方法，以及包含此类化合物的药物组合物。
• Hohenemser; Wolffenstein, Chemische Berichte, 1899, vol. 32, p. 2522
  作者：Hohenemser、Wolffenstein

  DOI：——

  日期：——
• Water Soluble Cannabinoids
  申请人：Martin Billy R.

  公开号：US20080064679A1

  公开（公告）日：2008-03-13

  Water-soluble cannabinoid compounds that are agonists of CB 1 and CB 2 cannabinoid receptors are provided. The compounds are made water-soluble by derivatization of the alkyl side chain and/or the phenolic hydroxyl group of tetrahydrocannabinol. The water-soluble cannabinoids are useful for the treatment of appetite loss, pain, multiple sclerosis, nausea and vomiting, and epilepsy.
• PKM2 MODULATORS AND METHODS FOR THEIR USE
  申请人：Tolero Pharmaceuticals, Inc.

  公开号：US20170015631A1

  公开（公告）日：2017-01-19

  Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
• CAMPTOTHECIN DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
  申请人：MARINE BIOMEDICAL RESEARCH INSTITUTE OF QINGDAO CO., LTD.

  公开号：US20220177485A1

  公开（公告）日：2022-06-09

  The present invention is directed to compounds according to Formula I as well as to stereoisomer, tautomer or pharmaceutically acceptable salts of such compounds. The invention also is directed to pharmaceutically acceptable compositions containing such compounds and associated methods for preparing and effect dose in treatment as well as the application in preparing medicine for preventing and/or treating cancers. The invention provides the novel derivatives which introduce methylenedioxy in the position of 10,11 and different groups in the position of 7. The derivatives of novel structure, and the raw materials are easily to obtain. In addition, the compounds in this invention have good cytotoxic activity in vitro and anti-tumor activity in vivo. Therefore, this kind of compounds have broad application foreground. The structure of derivatives are as follows: