二磷酸甲萘酚 | 84-98-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 二磷酸甲萘酚
• 英文名称: 2-methyl-1,4-bis-phosphonooxy-naphthalene
• 英文别名: 2-Methyl-1,4-bis-phosphonooxy-naphthalin；(2-Methyl-naphthalindiyl-(1.4))-bis-dihydrogenphosphat；(2-Methyl-naphthylen-(1.4))-bis-dihydrogenphosphat；1.4-Diphosphonooxy-2-methyl-naphthalin；menadiol diphosphate；2-Methyl-1,4-naphthochinol-(1.4)-bis-dihydrogenphosphat；(2-methyl-4-phosphonooxynaphthalen-1-yl) dihydrogen phosphate
• CAS: 84-98-0
• 化学式: C₁₁H₁₂O₈P₂
• 分子量: 334.159
• InChiKey: JTNHOVZOOVVGHI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  134
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  1,4-二羟基-2-甲基萘 在 吡啶 、 三氯氧磷 作用下， 生成 二磷酸甲萘酚
  参考文献：
  名称：

  Water-Soluble Antihemorrhagic Esters

  摘要：

  DOI：

  10.1021/ja01858a504

文献信息

• Solvent systems for pharmaceutical agents
  申请人：——

  公开号：US20020102280A1

  公开（公告）日：2002-08-01

  The invention provides compositions, solvent systems, and methods for solubilizing compounds which are otherwise difficult to solubilize. The invention involves the use of a structured fluid (e.g. a liquid crystalline phase, an L1 phase, an L2 phase, an L3 phase, an emulsion, or a microemulsion), comprising a polar solvent, a lipid or a surfactant, and an essential oil or a dissolution/solubilization agent.

  这项发明提供了用于溶解那些通常难以溶解的化合物的组合物、溶剂系统和方法。该发明涉及使用结构化流体（例如液晶相、L1相、L2相、L3相、乳化液或微乳化液），其中包括极性溶剂、脂质或表面活性剂以及精油或溶解/溶解剂。
• Diagnostic/therapeutic agents
  申请人：Klaveness Jo

  公开号：US20050002865A1

  公开（公告）日：2005-01-06

  Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.

  可定位的诊断和/或治疗活性剂，例如超声对比剂，包括悬浮在水载体液中的报告物，该报告物包含含气体或生成气体的材料，该剂能够与目标形成至少两种结合对。
• EXTERNAL PREPARATION CONTAINING VITAMIN D OR VITAMIN K
  申请人：Kita, Kiyoshi

  公开号：EP0862916A1

  公开（公告）日：1998-09-09

  An ophthalmic composition for treating and conditioning damaged tissue of the region of the eye which contains ergocalciferol or cholecalciferol, i.e., a vitamin D, as the active ingredient. An ophthalmic composition for preventing and treating disturbed metabolism in eye tissues which comprises a vitamin D or an active vitamin D as the active ingredient. An ophthalmic composition or a dermatological composition for protecting the skin or eyes from harmful ultraviolet radiation which comprises a vitamin D or an active vitamin D as the active ingredient. The ophthalmic composition normalizes the transparency or refraction of the eyeballs when administered to the region of the eye. When administered similarly, the ophthalmic composition further contributes to the amendment, healing or prevention of symptoms due to disturbed metabolism in eye tissue. The dermatological composition protects the skin from harmful ultraviolet radiation. It also protects scalp from harmful ultraviolet radiation to thereby relieve depilation. A cosmetic applied to the skin would inhibit the synthesis of vitamin D in the skin. It is, therefore, possible to supply vitamin D to the skin by applying the vitamin D-containing dermatological composition to a cosmetic.

  一种用于治疗和调节眼部受损组织的眼科组合物，其活性成分为麦角钙化醇或胆钙化醇，即一种维生素 D。一种用于预防和治疗眼部组织代谢紊乱的眼科组合物，其活性成分为维生素 D 或活性维生素 D。一种用于保护皮肤或眼睛免受有害紫外线辐射的眼科组合物或皮肤科组合物，其活性成分为维生素 D 或活性维生素 D。 眼科组合物用于眼球区域时，可使眼球的透明度或折射率正常化。以类似方式给药时，眼科组合物还有助于修正、治愈或预防因眼部组织新陈代谢紊乱而引起的症状。皮肤科组合物可保护皮肤免受有害紫外线辐射。它还能保护头皮免受有害紫外线辐射，从而缓解脱毛症状。涂抹在皮肤上的化妆品会抑制皮肤中维生素 D 的合成。因此，可以通过将含维生素 D 的皮肤组合物涂在化妆品上，为皮肤提供维生素 D。
• MEDICINAL COMPOSITIONS FOR TOPICAL ADMINISTRATION CONTAINING VITAMIN D AND VITAMIN K
  申请人：New Vision Co., Ltd.

  公开号：EP0998925A1

  公开（公告）日：2000-05-10

  Ophthalmic compositions for preventing corneal clouding and corneal refraction insufficiency, ultraviolet protective agents for protecting the ocular tissue or skin from harmful UV light, or antiallergic agents for topical administration, each containing vitamin Ds or vitamin Ks as the active ingredient.

  用于防止角膜混浊和角膜屈光不全的眼科组合物，用于保护眼部组织或皮肤免受有害紫外线伤害的紫外线防护剂，或用于局部用药的抗过敏剂，每种组合物都含有维生素 Ds 或维生素 Ks 作为活性成分。
• Drug releasing coatings for medical devices
  申请人：Lutonix, Inc.

  公开号：EP2092941A2

  公开（公告）日：2009-08-26

  The invention relates to a medical device for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent and additive. The additive has a hydrophilic part and a hydrophobic part and the therapeutic agent is not enclosed in micelles or encapsulated in particles or controlled release carriers.

  本发明涉及一种向组织输送治疗剂的医疗器械。该医疗器械的外表面覆盖有一层。该层含有治疗剂和添加剂。添加剂有亲水部分和疏水部分，治疗剂不包裹在胶束中，也不封装在颗粒或控释载体中。