(S)-3,3’-bis(2,4,6-triisopropylphenyl)-2’-(trimethylsilyloxy)-5,5’,6,6’,7,7’,8,8’-octahydro-1,1‘-binaphthyl-2-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (S)-3,3’-bis(2,4,6-triisopropylphenyl)-2’-(trimethylsilyloxy)-5,5’,6,6’,7,7’,8,8’-octahydro-1,1‘-binaphthyl-2-ol
• 英文别名: (S)-3,3'-bis(2,4,6-triisopropylphenyl)-2'-(trimethylsilyloxy)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl-2-ol；(S)-Trip2BitetTMS；(S)-3,3'-bis(2,4,6-triisopropylphenyl)-2'-(trimethylsilyloxy)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl-2-olate；1-[2-Trimethylsilyloxy-3-[2,4,6-tri(propan-2-yl)phenyl]-5,6,7,8-tetrahydronaphthalen-1-yl]-3-[2,4,6-tri(propan-2-yl)phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol
• 化学式: C₅₃H₇₄O₂Si
• 分子量: 771.255
• InChiKey: KYASTNUPEKYMOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  16.1
• 重原子数：
  56
• 可旋转键数：
  11
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  三氟甲磺酸三甲基硅酯 、 (R_a)-3,3’-bis(2,4,6-triisopropylphenyl)-5,5’,6,6’,7,7’,8,8’-octahydro-[1,1’-binaphthalene]-2,2’-diol 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以100%的产率得到(S)-3,3’-bis(2,4,6-triisopropylphenyl)-2’-(trimethylsilyloxy)-5,5’,6,6’,7,7’,8,8’-octahydro-1,1‘-binaphthyl-2-ol
  参考文献：
  名称：

  Highly Z-selective olefins metathesis

  摘要：

  本发明涉及催化剂和过程，用于通过同型烯烃交换反应从末端烯烃中Z-选择性地形成内部烯烃。

  公开号：

  US09079173B2

文献信息

• HIGHLY Z-SELECTIVE OLEFINS METATHESIS
  申请人：Schrock Richard R.

  公开号：US20110077421A1

  公开（公告）日：2011-03-31

  The present invention relates generally to catalysts and processes for the Z-selective formation of internal olefin(s) from terminal olefin(s) via homo-metathesis reactions.

  本发明通常涉及催化剂和过程，用于通过同型交换反应从末端烯烃中Z-选择性地形成内部烯烃。
• Highly Z-selective olefins metathesis
  申请人：Massachusetts Institute of Technology

  公开号：US09079173B2

  公开（公告）日：2015-07-14

  The present invention relates generally to catalysts and processes for the Z-selective formation of internal olefin(s) from terminal olefin(s) via homo-metathesis reactions.

  本发明涉及催化剂和过程，用于通过同型烯烃交换反应从末端烯烃中Z-选择性地形成内部烯烃。
• Highly <i>Z</i>-Selective Metathesis Homocoupling of Terminal Olefins
  作者：Annie J. Jiang、Yu Zhao、Richard R. Schrock、Amir H. Hoveyda

  DOI：10.1021/ja908098t

  日期：2009.11.25

  Mo and W MonoAryloxide-Pyrrolide (MAP) otefin metathesis catalysts can couple terminal olefins to give as high as >98% Z-products in moderate to high yields with as little as 0.2% catalyst. Results are reported for 1-hexene, 1-octene, allylbenzene, allyltrimethylsilane, methyl-10-undecenoate, methyl-9-decenoate, allylB(pinacolate), allyloBenzyl, allylNHTosyl, and allylNHPh. It is proposed that high Z-selectivity is achieved because a large aryloxide only allows metallacyclobutanes to form that contain adjacent cis substituents and because isomerization of Z-product to E-product can be stow in that same steric environment.