伽升沃E | 112649-21-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 中文名称: 伽升沃E
• 英文名称: garcinone E
• 英文别名: 2,3,6,8-tetrahydroxy-1,4,7-tris(3-methylbut-2-enyl)xanthen-9-one
• CAS: 112649-21-5
• 化学式: C₂₈H₃₂O₆
• 分子量: 464.558
• InChiKey: WVJYEKGQSBGNRP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.9
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  107
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  伽升沃E 在 盐酸 、 甲醇 作用下， 生成 15-Hydroxy-3,3,6,6,12,12-hexamethyl-1,2,3,6,7,8,12,13-octahydro-14H-4,5,9,11-tetraoxa-dibenzo[a,c]naphthacen-16-one
  参考文献：
  名称：

  Dutta, P. K.; Sen, A. K.; Sarkar, K. K., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1987, vol. 26, # 1-12, p. 281 - 282

  摘要：

  DOI：

文献信息

• Xanthone-rich plant extracts or compounds therefrom for modulating diseases of the central nervous system and related disorders
  申请人：Deakin University

  公开号：US10568862B2

  公开（公告）日：2020-02-25

  The invention relates to a method of treatment and/or prophylaxis of a disease or disorder of the central nervous system comprising administering to a mammal in need thereof an effective amount of a xanthone-rich plant extract, or a compound derived from a xanthone-rich plant extract. The invention also relates to use of a xanthone-rich plant extract, or a compound derived from a xanthone-rich plant extract, in the preparation of a medicament for the treatment and/or prophylaxis of a disease or disorder of the central nervous system and to a xanthone-rich plant extract, or a compound derived from a xanthone-rich plant extract, for use in the treatment and/or prophylaxis of a disease or disorder of the central nervous system.

  本发明涉及一种治疗和/或预防中枢神经系统疾病或紊乱的方法，包括向需要的哺乳动物施用有效量的富含黄酮的植物提取物或从富含黄酮的植物提取物衍生的化合物。 本发明还涉及富含黄酮的植物提取物或由富含黄酮的植物提取物衍生的化合物在制备治疗和/或预防中枢神经系统疾病或紊乱的药物中的用途，以及富含黄酮的植物提取物或由富含黄酮的植物提取物衍生的化合物在治疗和/或预防中枢神经系统疾病或紊乱中的用途。
• DUTTA, P. K.;SEN, A. K.;SARKAR, K. K.;BANERJI, N., INDIAN J. CHEM., 26,(1987) N 3, 281-282
  作者：DUTTA, P. K.、SEN, A. K.、SARKAR, K. K.、BANERJI, N.

  DOI：——

  日期：——
• The Structure of Garcinone E.
  作者：Shin-ichiro SAKAI、Makiko KATSURA、Hiromitsu TAKAYAMA、Norio AIMI、Nantarit CHOKETHAWORN、Maitree SUTTAJIT

  DOI：10.1248/cpb.41.958

  日期：——

  As part of a survey of anti-tumorpromotive chemicals, garcinone E (1) and nine known xanthones, 8-deoxygartanin, gartanin, xanthone I, β-mangostin, garcinone B, 6-deoxy-γ-mangostin, 1, 5, 8-trihydroxy-3-methoxy-2-(3-methyl-2-butenyl)xanthone, γ-mangostin and α-mangostin, together with egonol, were isolated from the fruit hulls of Garcinia mangostana L. collected in Thailand. The structure of garcinone E was elucidated as 1, 3, 6, 7-tetrahydroxy-2, 5, 8-tri-(3-methyl-2-buteny)xanthone by spectroscopic methods, including the application of a number of two dimensional (2D)NMR techniques (1H-1H, 13C-1H correlation spectroscopy (COSY), nuclear Overhauser effect spectroscopy (NOESY) and correlation via long-range coupling (COLOC).
• XANTHONE-RICH PLANT EXTRACTS OR COMPOUNDS THEREFROM FOR MODULATING DISEASES OF THE CENTRAL NERVOUS SYSTEM AND RELATED DISORDERS
  申请人：DEAKIN UNIVERSITY

  公开号：EP3110414B1

  公开（公告）日：2020-09-30
• Compositions from Garcinia as Aromatase Inhibitors for Breast Cancer Chemoprevention and Chemotherapy
  申请人：Balunas Marcy J.

  公开号：US20090181110A1

  公开（公告）日：2009-07-16

  Aromatase inhibitors (AIs) are disclosed which are useful in the treatment and prevention of post-menopausal breast cancer. New AIs derived from natural products are disclosed that are evaluated for clinical utility for treating post-menopausal breast cancer and may also act as chemopreventive agents for preventing breast cancer. Several pure compounds demonstrated AI activity using a noncellular, enzyme-based microsomal and a cell-based aromatase assay. Correlations are made between structural classes with levels of aromatase inhibition. The disclosure may be utilized to direct synthetic modification of natural product scaffolds to enhance aromatase inhibition or to standardize botanical dietary supplements for increased aromatase inhibition activity.