carbonic acid bis(2-oxo-[1,3]dioxolan-4-ylmethyl)ester

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: carbonic acid bis(2-oxo-[1,3]dioxolan-4-ylmethyl)ester
• 英文别名: diglycerol tricarbonate；DGTC；carbonic acid bis-(2-oxo-[1,3]dioxolan-4-ylmethyl ester)；Kohlensaeure-bis-(2-oxo-[1,3]dioxolan-4-ylmethylester)；Glycerincarbonat；Bis-(glycerin-1,2-carbonat)-3,3'-carbonat；Bis[(2-oxo-1,3-dioxolan-4-yl)methyl] carbonate
• 化学式: C₉H₁₀O₉
• 分子量: 262.173
• InChiKey: HPJCBAFQPHJREU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  107
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  methyl (1,3-dioxolan-2-on-4-yl)methyl carbonate 在 calcium oxide 作用下， 反应 27.0h， 生成 carbonic acid bis(2-oxo-[1,3]dioxolan-4-ylmethyl)ester
  参考文献：
  名称：

  New efficient and recyclable catalysts for the synthesis of di- and tri-glycerol carbonates

  摘要：

  混合氧化物已被用于将甘油转化为DGDC和DGTC，使用DMC或尿素。

  DOI：

  10.1039/c5ra06981e

文献信息

• [EN] QUINOLONE-3-DIARYLETHERS<br/>[FR] QUINOLONE-3-DIARYLÉTHERS
  申请人：UNIV OREGON HEALTH & SCIENCE

  公开号：WO2017015360A1

  公开（公告）日：2017-01-26

  Disclosed are derivative compounds of ELQ-300 that include an ester at position 4. These compounds have enhanced properties relative to ELQ-300. Also disclosed are pharmaceutical compositions comprising the compounds and methods of treating and preventing malaria infections involving administering the pharmaceutical compositions to the subject.

  揭示了ELQ-300的衍生化合物，其中在位置4处包含酯基。这些化合物相对于ELQ-300具有增强的性质。还揭示了包括这些化合物的药物组合物以及治疗和预防涉及向受试者施用这些药物组合物的疟疾感染的方法。
• Continuous-Flow<i>O</i>-Alkylation of Biobased Derivatives with Dialkyl Carbonates in the Presence of Magnesium-Aluminium Hydrotalcites as Catalyst Precursors
  作者：Lisa Cattelan、Alvise Perosa、Piero Riello、Thomas Maschmeyer、Maurizio Selva

  DOI：10.1002/cssc.201601765

  日期：2017.4.10

  The base‐catalysed reactions of OH‐bearing biobased derivatives (BBDs) including glycerol formal, solketal, glycerol carbonate, furfuryl alcohol and tetrahydrofurfuryl alcohol with non‐toxic dialkyl carbonates (dimethyl and diethyl carbonate) were explored under continuous‐flow (CF) conditions in the presence of three Na‐exchanged Y‐ and X‐faujasites (FAUs) and four Mg–Al hydrotalcites (HTs). Compared

  在连续流（CF）条件下研究了含OH的生物基衍生物（BBD）的碱催化反应，包括甘油缩甲醛，单缩醛，碳酸甘油酯，糠醇和四氢糠醇与无毒的碳酸二烷基酯（碳酸二甲酯和碳酸二乙酯）在三个Na交换Y和X八面沸石（FAU）和四个Mg-Al水滑石（HT）存在的情况下。与以前的由碳酸二烷基酯介导的醚化方案相比，所报道的方法不仅在（化学）选择性方面，而且在催化剂的可循环性，后处理，产品纯化的简便性以及重要的是工艺强化方面都提供了实质性的改进。表征研究证明，HT30和KW2000水滑石都可作为催化剂前体：在热活化预处理中，
• METHOD FOR PREPARING POLYHYDROXY-URETHANES
  申请人：BERNARD Jean-Marie

  公开号：US20110288230A1

  公开（公告）日：2011-11-24

  The invention relates to a method for preparing polyhydroxy-urethanes without using a compound having an isocyanate function, and from amino compounds and compounds carrying carbonate functions, in particular cyclic carbonate functions. The invention also relates to a method for preparing aqueous or hydro-organic formulations containing polyhydroxy-urethanes, and to the use of said polyhydroxy-urethanes and of said aqueous or hydro-organic formulations.

  本发明涉及一种无需使用具有异氰酸酯功能的化合物，而是利用氨基化合物和携带碳酸酯功能，特别是环状碳酸酯功能的化合物制备聚羟基脲的方法。本发明还涉及一种制备含聚羟基脲的水性或水-有机配方的方法，以及所述聚羟基脲和所述水性或水-有机配方的使用。
• Quinolone-3-diarylethers
  申请人：OREGON HEALTH & SCIENCE UNIVERSITY

  公开号：US10584098B2

  公开（公告）日：2020-03-10

  Disclosed are derivative compounds of ELQ-300 that include an ester at position 4. These compounds have enhanced properties relative to ELQ-300. Also disclosed are pharmaceutical compositions comprising the compounds and methods of treating and preventing malaria infections involving administering the pharmaceutical compositions to the subject.

  所公开的是 ELQ-300 的衍生物化合物，其中包括位于第 4 位的酯。与 ELQ-300 相比，这些化合物具有更强的特性。还公开了包含这些化合物的药物组合物，以及治疗和预防疟疾感染的方法，其中包括给受试者施用药物组合物。
• Recyclable biocatalytic composites of lipase-linked magnetic macro-/nano-particles for glycerol carbonate synthesis
  作者：Madalina Tudorache、Loredana Protesescu、Alina Negoi、Vasile I. Parvulescu

  DOI：10.1016/j.apcata.2012.06.016

  日期：2012.9

  Lipase immobilized biocatalysts were prepared via enzyme binding onto functionalized surface of magnetic micro-/nano-particles. In order to achieve an efficient biocatalytic composite the immobilization parameters (e.g. lipase concentration, pH of the immobilization phase, activation reagent) were correlated with support morphology and type of the functional group on the support surface. The characterization of the lipase-particle composites was made using FTIR and UV-Vis techniques. The biocatalyst activity was evaluated in the transesterification reaction of glycerol with DMC (dimethyl carbonate). Under solvent-free conditions the conversion of glycerol was of 48.6% with the selectivity in glycerol carbonate (GlyC) of 85%. The biocatalyst composites were easily recycled using the magnetic properties of the support. Compared to free enzyme, recycling experiments demonstrated that the operational stability of the heterogeneous biocatalyst was improved (fifteen cycles for bio-composites vs. four cycles for free enzyme). (C) 2012 Elsevier BM. All rights reserved.