N-decyl-N-(difluoromethyl)piperidinium chloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-decyl-N-(difluoromethyl)piperidinium chloride
• 英文别名: 1-Decyl-1-(difluoromethyl)piperidin-1-ium;chloride
• 化学式: C₁₆H₃₂F₂N*Cl
• 分子量: 311.887
• InChiKey: CIBSJEUCDCQWQP-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  2.35
• 重原子数：
  20
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-癸基哌啶 、 氟里昂-22 在 sodium hydroxide 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 3.5h， 以96%的产率得到N-decyl-N-(difluoromethyl)piperidinium chloride
  参考文献：
  名称：

  Difluoromethyltrialkylammonium SaltsTheir Expeditious Synthesis from Chlorodifluoromethane and Tertiary Amines in the Presence of Concentrated Aqueous Sodium Hydroxide. The Catalytic Process

  摘要：

  [GRAPHICS]We found that difluorocarbene generated from chlorodifluoromethane with 50% aqueous sodium hydroxide reacts with lipophilic tertiary amines 1a-g giving difluoromethyltrialkylammonium chlorides 2a-g in high yields. Similarly, difluoromethyltrialkylammonium iodides 3h-l, nitrates 4h-k, or isothiocyanates 5i,j were synthesized from hydrophilic tertiary amines 1h-l and the corresponding sodium or potassium salts. The process is catalytic with respect to the base used.

  DOI：

  10.1021/jo701735n

文献信息

• Difluoromethyltrialkylammonium SaltsTheir Expeditious Synthesis from Chlorodifluoromethane and Tertiary Amines in the Presence of Concentrated Aqueous Sodium Hydroxide. The Catalytic Process
  作者：Ewelina Nawrot、Andrzej Joñczyk

  DOI：10.1021/jo701735n

  日期：2007.12.1

  [GRAPHICS]We found that difluorocarbene generated from chlorodifluoromethane with 50% aqueous sodium hydroxide reacts with lipophilic tertiary amines 1a-g giving difluoromethyltrialkylammonium chlorides 2a-g in high yields. Similarly, difluoromethyltrialkylammonium iodides 3h-l, nitrates 4h-k, or isothiocyanates 5i,j were synthesized from hydrophilic tertiary amines 1h-l and the corresponding sodium or potassium salts. The process is catalytic with respect to the base used.