1-(Methanesulfonyl)-3-chloro-propanol

• 分子结构分类: 有机化合物 - 有机硫化合物 - 磺酰类
• 英文名称: 1-(Methanesulfonyl)-3-chloro-propanol
• 英文别名: 1-(methanesulfonyl)-3-chloropropanol；3-chloro-1-methylsulfonylpropan-1-ol
• 化学式: C₄H₉ClO₃S
• 分子量: 172.633
• InChiKey: OFJWDHQXYYGJIP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  62.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  甲基磺酰氯 、 3-氯-1-丙醇 在 三乙胺 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 以335 g (65%)的产率得到1-(Methanesulfonyl)-3-chloro-propanol
  参考文献：
  名称：

  Nitrogenous macrocyclic compounds

  摘要：

  新型大环化合物被构建成包含至少一个环系统打断的大环结构。每个打断的环系统包括两个桥头原子。桥头原子与一个或多个桥连接，连接一个或多个环系统，从而形成一个大环结构。每个桥中都含有两个或更多的氮基团，这些氮基团经过化学官能团衍生。环系统可以包括进一步的氮基团，可以是环原子，也可以是连接到环上的侧链基团。这些也可以经过化学官能团衍生。化学官能团的总体赋予大环化合物特定的构象和其他性质。根据发明的某些实施例，利用化学官能团和氮基团的排列组合制备这种大环化合物的文库，以在文库中构建复杂性。

  公开号：

  US06107482A1

文献信息

• Oligomeric compounds having nitrogen-containing linkages
  申请人：ISIS Pharmaceuticals, Inc.

  公开号：US06121433A1

  公开（公告）日：2000-09-19

  Novel compounds and libraries of compounds based on nitrogen atoms that are joined together with spanner groups include "letters" i.e., functional groups, that are attached to the nitrogen atoms, to the spanner groups or to both the nitrogen atoms and the spanner groups to render the compounds and libraries of such compounds with diverse properties.

  基于氮原子的连接用跨链基团的新化合物和化合物库，包括“字母”，即连接到氮原子，跨链基团或同时连接到氮原子和跨链基团的功能基团，以使这些化合物和化合物库具有多种性质。
• Macrocyclic compounds having nitrogen-containing linkages
  申请人：Isis Pharmaceuticals, Inc.

  公开号：US06207826B1

  公开（公告）日：2001-03-27

  Novel macrocyclic compounds are constructed to include a ring or ring system having two bridgehead atoms with a bridge extending between the bridgehead atoms. Located in at least the bridge are two or more nitrogenous moieties that are derivatized with chemical functional groups. The ring or ring systems can include further nitrogenous moieties, either as ring atoms or on pendant groups attached to the ring. These can also be derivatized with chemical functional groups. The totality of the chemical functional groups imparts certain conformational and other properties to the compounds. In accordance with certain embodiments of the invention, libraries of such compounds are prepared utilizing permutations and combinations of the chemical functional groups and the nitrogenous moieties to build complexity into the library.

  新型大环化合物被构建，包括一个具有两个桥头原子和桥梁的环或环系统延伸在桥头原子之间。至少在桥梁中，有两个或更多的含氮基团被化学官能团衍生。环或环系统可以包括进一步的含氮基团，作为环原子或附着在环上的吊坠基团。这些也可以被化学官能团衍生。化学官能团的总体赋予化合物某些构象和其他性质。根据发明的某些实施方式，利用化学官能团和含氮基团的排列组合来构建复杂性的化合物库。
• Methods for processing chemical compounds having reactive functional groups
  申请人：Cook Phillip Dan

  公开号：US06942966B1

  公开（公告）日：2005-09-13

  Novel macrocyclic compounds are constructed to include large cyclic structures that are interrupted by at least one ring system. Each interrupting ring system includes two bridgehead atoms. Bridgehead atoms are bonded to one or more bridges that interconnect one or more ring systems thereby forming a large cyclic structure. Located in each bridge are two or more nitrogenous moieties that are derivatized with chemical functional groups. The ring systems can include further nitrogenous moieties, either as ring atoms or on pendant groups attached to the ring. These can also be derivatized with chemical functional groups. The totality of the chemical functional groups imparts certain conformational and other properties to the macrocyclic compounds. In accordance with certain embodiments of the invention, libraries of such macrocyclic compounds are prepared utilizing permutations and combinations of the chemical functional groups and the nitrogenous moieties to build complexity into the library.

  构建了新型的大环化合物，其中包括至少一个环系统中断的大环结构。每个中断的环系统包括两个桥头原子。桥头原子与一个或多个桥连接，相互连接一个或多个环系统，从而形成一个大的环结构。每个桥中都有两个或更多的氮基官能团，这些氮基官能团被衍生化学官能团。环系统可以包括进一步的氮基官能团，可以是环原子或附着在环上的侧链基团。这些也可以被衍生化学官能团。化学官能团的总体影响赋予大环化合物某些构象和其他性质。根据本发明的某些实施例，利用氮基官能团和化学官能团的排列组合制备这种大环化合物的文库，以将复杂性引入文库中。
• Nitrogenous macrocyclic compounds
  申请人：Isis Pharmaceuticals, Inc.

  公开号：US06107482A1

  公开（公告）日：2000-08-22

  Novel macrocyclic compounds are constructed to include large cyclic structures that are interrupted by at least one ring system. Each interrupting ring system includes two bridgehead atoms. Bridgehead atoms are bonded to one or more bridges that interconnect one or more ring systems thereby forming a large cyclic structure. Located in each bridge are two or more nitrogenous moieties that are derivatized with chemical functional groups. The ring systems can include further nitrogenous moieties, either as ring atoms or on pendant groups attached to the ring. These can also be derivatized with chemical functional groups. The totality of the chemical functional groups imparts certain conformational and other properties to the macrocyclic compounds. In accordance with certain embodiments of the invention, libraries of such macrocyclic compounds are prepared utilizing permutations and combinations of the chemical functional groups and the nitrogenous moieties to build complexity into the library.

  新型大环化合物被构建成包含至少一个环系统打断的大环结构。每个打断的环系统包括两个桥头原子。桥头原子与一个或多个桥连接，连接一个或多个环系统，从而形成一个大环结构。每个桥中都含有两个或更多的氮基团，这些氮基团经过化学官能团衍生。环系统可以包括进一步的氮基团，可以是环原子，也可以是连接到环上的侧链基团。这些也可以经过化学官能团衍生。化学官能团的总体赋予大环化合物特定的构象和其他性质。根据发明的某些实施例，利用化学官能团和氮基团的排列组合制备这种大环化合物的文库，以在文库中构建复杂性。