全氟庚酸酐 | 78225-99-7

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代烷
• 中文名称: 全氟庚酸酐
• 英文名称: perfluoroheptanoic anhydride
• 英文别名: 2,2,3,3,4,4,5,5,6,6,7,7,7-tridecafluoroheptanoyl 2,2,3,3,4,4,5,5,6,6,7,7,7-tridecafluoroheptanoate
• CAS: 78225-99-7
• 化学式: C₁₄F₂₆O₃
• 分子量: 710.111
• InChiKey: NWDZSYHMBYNCRO-UHFFFAOYSA-N

物化性质

• 沸点：
  223.9±40.0 °C(Predicted)
• 密度：
  1.764±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  8.8
• 重原子数：
  43
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  29

安全信息

• 危险品标志：
  C
• 安全说明：
  S26,S36/37/39
• 危险类别码：
  R34
• 海关编码：
  2915900090
• 危险品运输编号：
  UN 3265

反应信息

• 作为反应物：
  描述：

  全氟庚酸酐 在 吡啶 、 四氯化钛 作用下， 以 二氯甲烷 为溶剂， 反应 20.0h， 生成 methyl 6-(tridecafluorohexyl)salicylate
  参考文献：
  名称：

  1，3-双（甲硅烷基烯醇醚）与3-乙氧基-1-（全氟烷基）丙-2-烯-1-酮的[3 + 3]环化反应合成6-（全氟烷基）水杨酸酯

  摘要：

  通过用3-乙氧基-1-（全氟烷基）丙-2-烯-1-酮对1,3-双（甲硅烷基烯醇醚）进行[3 + 3]环化制备6-（全氟烷基）水杨酸酯。

  DOI：

  10.1016/j.tet.2006.10.062

文献信息

• Methods for Making Functionalized Fluorinated Monomers, Fluorinated Monomers, and Compositions for Making the Same
  申请人：Etna-TEC, Ltd.

  公开号：US20180334417A1

  公开（公告）日：2018-11-22

  A method of making a functionalized fluorinated monomer for use in making oligomers and polymers that can be used to improve surface properties of polymer-derived systems, such as coatings. The method of making a functionalized fluorinated monomer includes reacting at least one fluorinated nucleophilic reactant, such as a fluorinated alcohol, with at least one compound containing at least one epoxide group. Other methods include reaction of a fluorinated alcohol with a cyclic carboxylic anhydride. In another embodiment, a method includes reacting a fluorinated mesylate, tosylate or triflate with an amine, alkoxide or phenoxide. In other embodiments, the method includes reacting a fluorinated alcohol with an alkyl halide, or reacting a fluorinated alkyl halide with an amine. The functionalized fluorinated monomers may be used as intermediates and reacted to modify the functional groups thereon. Further, the functionalized fluorinated monomers may be reacted to form polymers or oligomers, or with polymers or oligomers having functional groups to modify the polymer or oligomer through the functional group thereon,

  一种制备用于制备寡聚物和聚合物的官能化氟化单体的方法，可用于改善聚合物衍生系统（如涂层）的表面性能。制备官能化氟化单体的方法包括将至少一种氟化亲核试剂（如氟化醇）与至少一种含有至少一个环氧基团的化合物反应。其他方法包括将氟化醇与环状羧酸酐反应。在另一实施例中，一种方法包括将氟化甲磺酸酯、对甲苯磺酸酯或三氟甲烷磺酸酯与胺、烷氧基或苯氧基反应。在其他实施例中，该方法包括将氟化醇与烷基卤化物反应，或将氟化烷基卤化物与胺反应。这些官能化氟化单体可用作中间体，并可反应以修改其上的官能基团。此外，这些官能化氟化单体可用于与聚合物或寡聚物反应，或与具有官能基团的聚合物或寡聚物反应，通过其上的官能基团修改聚合物或寡聚物。
• Compositions of iodophenyl esters and iodophenyl sulfonates in
  申请人：Sterling Winthrop Inc.

  公开号：US05336484A1

  公开（公告）日：1994-08-09

  Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a polymeric material capable of forming a coating on the gastrointestinal tract and an x-ray producing agent of the formula ##STR1## and methods for their use in diagnostic radiology of the gastrointestinal tract wherein ##STR2## Z=H, halo, C.sub.1 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups; R=C.sub.1 -C.sub.25 alkyl, cycloalkyl, aryl or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, lower-alkoxy, hydroxy, carboxy or lower-alkoxy carbonyl, lower-alkenyl, lower-alkynyl, lower-alkylene or lower-alkoxy-carbonyloxy, n is 1-5; y is 0-4; and w is 1-4.

  本公开了用于口服或逆行检查消化道的X射线造影剂组合物，包括能够在消化道形成涂层的聚合物材料和具有以下公式的X射线产生剂：##STR1##以及它们在消化道诊断放射学中的使用方法，其中##STR2##Z=H，卤素，C.sub.1 -C.sub.20烷基，环烷基，低烷氧基，氰基，其中烷基和环烷基基团可被卤素或卤素-低烷基基团取代；R=C.sub.1 -C.sub.25烷基，环烷基，芳基或卤素-低烷基，可选地被卤素，氟-低烷基，低烷氧基，羟基，羧基或低烷氧基羰基，低烯基，低炔基，低烷基烯基或低烷氧基羰基氧基取代，n为1-5；y为0-4；w为1-4。
• Compositions of iodophenyl sulfonates for X-ray visualization of the
  申请人：Sterling Winthrop, Inc.

  公开号：US05468466A1

  公开（公告）日：1995-11-21

  Disclosed are contrast agents of the formula ##STR1## contained in aqueous compositions and methods for their use in diagnostic radiology of the gastrointestinal tract wherein ##STR2## Z=H, halo, C.sub.1 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups; R=C.sub.1 -C.sub.25 alkyl, cycloalkyl, aryl, or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, lower-alkoxy, hydroxy, carboxy or lower-alkoxy carbonyl, lower-alkenyl, lower-alkynyl, lower-alkylene, lower-alkoxy-carbonyloxy; n=1-5; y=0-4; and w=1-4 in an aqueous pharmaceutically acceptable carrier.

  本发明涉及一种公式为##STR1##的造影剂，其含于水性组合物中，并用于胃肠道诊断放射学中的方法，其中##STR2##Z=H，卤素，C.sub.1-C.sub.20烷基，环烷基，低烷氧基，氰基，其中烷基和环烷基可以用卤素或卤素-低烷基代替；R=C.sub.1-C.sub.25烷基，环烷基，芳基或卤素-低烷基，可选地被卤素，氟-低烷基，低烷氧基，羟基，羧基或低烷氧基羰基，低烯基，低炔基，低烷基，低烷氧基羰氧基取代；n=1-5；y=0-4；w=1-4，含于水性药学可接受载体中。
• Compositions of iodophenyl esters for X-ray visualization of the
  申请人：Sterling Winthrop Inc.

  公开号：US05318769A1

  公开（公告）日：1994-06-07

  Disclosed are contrast agents of the formula ##STR1## contained in aqueous compositions and methods for their use in diagnostic radiology of the gastrointestinal tract wherein X= ##STR2## Z=H, halo, C.sub.1 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups; R=C.sub.1 -C.sub.25 alkyl, cycloalkyl, aryl, or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, lower-alkoxy, hydroxy, carboxy or lower-alkoxy carbonyl, lower-alkenyl, lower-alkynyl, lower-alkylene, lower-alkoxy-carbonyloxy; n=1-5; y=0-4; and w=1-4 in an aqueous pharmaceutically acceptable carrier.

  本发明涉及一种公式为##STR1##的对比剂，包含在水溶液中，以及它们在胃肠道诊断放射学中的使用方法，其中X=##STR2##，Z=H，卤素，C.sub.1-C.sub.20烷基，环烷基，较低的烷氧基，氰基，其中烷基和环烷基可以用卤素或卤素较低烷基基团取代；R=C.sub.1-C.sub.25烷基，环烷基，芳基或卤素较低烷基，可选地取代卤素，氟较低烷基，较低烷氧基，羟基，羧基或较低烷氧基羰基，较低烯基，较低炔基，较低烷基，较低烷氧基羰氧基，n=1-5，y=0-4，w=1-4，以水制剂为载体。
• Compositions of iodophenyl esters and iodophenyl sulfonates in film-forming materials for visualization of the gastrointestinal tract
  申请人：NYCOMED IMAGING AS

  公开号：EP0617970A2

  公开（公告）日：1994-10-05

  Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a polymeric material capable of forming a coating on the gastrointestinal tract, said polymeric material having atoms containing polarizable electrons thereon, in combination with a divalent cation; and an x-ray contrast producing agent of the formula or a pharmaceutically accetable salt thereof, wherein X = or Z = H, halo, C1-C20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups; R = C1-C25 alkyl, cycloalkyl, aryl or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, lower-alkoxy, hydroxy, carboxy or lower-alkoxy carbonyl, lower-alkenyl, lower-alkynyl, lower-alkylene or lower-alkoxy-carbonyloxy, n is 1-5; y is 0-4; and w is 1-4, in a pharmaceutically acceptable carrier and a method of its use in diagnostic radiology of the GI tract.

  本发明公开了用于胃肠道口腔或逆行检查的 X 射线造影剂组合物，该组合物包括一种可在胃肠道上形成涂层的聚合材料，所述聚合材料上有含有可极化电子的原子，并与二价阳离子结合；以及一种X射线造影剂，其式为 或其可药用盐、 其中 X = 或 Z = H、卤素、C1-C20 烷基、环烷基、低级烷氧基、氰基，其中烷基和环烷基可被卤素或卤代低级烷基取代； R = C1-C25 烷基、环烷基、芳基或卤代低烷基，可任选被卤代、氟代低烷基、低烷氧基、羟基、羧基或低烷氧基羰基、低烯基、低炔基、低亚烷基或低烷氧基羰氧基取代、 n 是 1-5 y 是 0-4；以及 w 为 1-4、 在药学上可接受的载体中，及其在消化道放射诊断中的使用方法。