(4-ethylpiperazin-1-yl)(phenyl)methanethione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (4-ethylpiperazin-1-yl)(phenyl)methanethione
• 英文别名: (4-Ethylpiperazin-1-yl)-phenylmethanethione
• 化学式: C₁₃H₁₈N₂S
• mdl: MFCD09539586
• 分子量: 234.365
• InChiKey: IIKLILSCPFKVJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.461
• 拓扑面积：
  38.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (4-ethylpiperazin-1-yl)(phenyl)methanone 在 劳森试剂 作用下， 反应 0.13h， 生成 (4-ethylpiperazin-1-yl)(phenyl)methanethione
  参考文献：
  名称：

  微波辅助的无溶剂硫代酰胺的平行合成

  摘要：

  描述了硫酰胺的快速平行合成。利用劳氏试剂作为氧/硫交换试剂，将酰基氯和二胺混合而合成的酰胺库转化为相应的硫代酰胺。通过固相萃取纯化提供足够纯度和产率的文库成员。

  DOI：

  10.1016/s0040-4039(00)01360-5

文献信息

• Microwave-assisted iodine-catalyzed oxidative coupling of dibenzyl(difurfuryl)disulfides with amines: a rapid and efficient protocol for thioamides
  作者：Jinyang Chen、Lan Mei、Jialing Liu、Chuntao Zhong、Binfang Yuan、Qiang Li

  DOI：10.1039/c9ra05939c

  日期：——

  efficient protocol for synthesis of thioamides was developed via the microwave-assisted iodine-catalyzed oxidative coupling of dibenzyl(difurfuryl)disulfides with amines. This process is scalable and tolerates a wide spectrum of amines to deliver the corresponding products in moderate to excellent yields in 10 minutes, providing a cheap and rapid approach to thioamides.

  通过微波辅助碘催化二苄基（二糠基）二硫化物与胺的氧化偶联，开发了一种合成硫代酰胺的有效方案。该工艺具有可扩展性，可耐受多种胺类，从而在 10 分钟内以中等至优异的产率提供相应的产品，为硫代酰胺提供了一种廉价且快速的方法。
• Iodine-Promoted Synthesis of Thioamides from 1,2-Dibenzyl­sulfane and Difurfuryl Disulfide
  作者：Xinhua Xu、Renhua Qiu、Sihai Chen、You Li、Jinyang Chen、Lebin Su、Zhi Tang、Chak-Tong Au

  DOI：10.1055/s-0035-1562509

  日期：——

  Thioamides can be generated at 100 degrees C in high yield through the reaction of 1,2-dibenzyldisulfane with difurfuryldisulfide using iodine as oxidant and DMSO as solvent. The protocol is metal- and additive-free, providing a convenient and economical way for the synthesis of various kinds of thioamides under mild conditions.
• Microwave-assisted solvent-free parallel synthesis of thioamides
  作者：Roger Olsson、Henrik C Hansen、Carl-Magnus Andersson

  DOI：10.1016/s0040-4039(00)01360-5

  日期：2000.10

  Rapid parallel synthesis of thioamides is described. A library of amides, synthesised by mixing acyl chlorides and diamines, was transformed into the corresponding thioamides utilising Lawesson's reagent as the oxygen/sulphur exchange reagent. Purification by solid-phase extraction afforded the library members in adequate purities and yields.

  描述了硫酰胺的快速平行合成。利用劳氏试剂作为氧/硫交换试剂，将酰基氯和二胺混合而合成的酰胺库转化为相应的硫代酰胺。通过固相萃取纯化提供足够纯度和产率的文库成员。