内吸磷 | 8065-48-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机硫代磷酸及其衍生物
• 中文名称: 内吸磷
• 中文别名: 1059乳剂；杀虱多；一0五九；O,O-二乙基-O-〔2-(乙硫基)乙基〕硫代磷酸酯和O,O-二乙基-S-〔2-(乙硫基)乙基〕硫代磷酸酯混剂；一O五九
• 英文名称: Demeton
• 英文别名: diethoxy-(2-ethylsulfanylethoxy)-sulfanylidene-λ5-phosphane;1-diethoxyphosphorylsulfanyl-2-ethylsulfanylethane
• CAS: 8065-48-3
• 化学式: C16H38O6P2S4
• 分子量: 516.7
• InChiKey: FAXIJTUDSBIMHY-UHFFFAOYSA-N

物化性质

• 稳定性/保质期：
  生产设备需处于密闭状态，并确保车间内部有良好的通风条件。操作时，请务必佩戴好劳动保护用品，以保障生产安全。

计算性质

• 辛醇/水分配系数(LogP)：
  6.71
• 重原子数：
  28
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  171
• 氢给体数：
  0
• 氢受体数：
  10

ADMET

代谢

代谢和降解速率在小鼠、蟑螂和植物中是不同的/小鼠的代谢和降解速率高于昆虫，而昆虫的又高于植物/。然而，在每种情况下，代谢途径和代谢物是相同的。主要代谢... /途径/ 对于两种异构体都是将2-乙硫基醚氧化成亚砜和砜。在敌草快的例子中，次要的... /途径/ 涉及将P=S氧化成P=O，随后再氧化成亚砜和砜。... 应用到植物后，敌草快-S迅速产生了至少3种代谢物，其中2种持续存在长达15周。使用色谱技术，其中2种化合物被鉴定为相应的亚砜和砜。

... RATES OF METABOLISM & DEGRADATION /WERE DIFFERENT IN MICE, COCKROACHES & PLANTS/ ... RATES WERE GREATER IN THE MAMMAL THAN IN THE INSECT & GREATER IN THE INSECT THAN IN PLANTS. ROUTES OF METABOLISM & METABOLITES, HOWEVER, WERE THE SAME IN EACH CASE. THE PRINCIPAL METABOLIC ... /PATHWAY/ FOR BOTH ISOMERS WAS OXIDN OF THE 2-ETHYLTHIO ETHER TO SULFOXIDE & SULFONE. IN CASE OF DEMETON O, A SECONDARY ... /PATHWAY/ INVOLVED OXIDN OF P=S TO P=O WITH SUBSEQUENT OXIDN TO SULFOXIDE & SULFONE. ... FOLLOWING APPLICATION TO PLANTS, DEMETON-S RAPIDLY GAVE RISE TO AT LEAST 3 METABOLITES, 2 OF WHICH PERSISTED FOR AS LONG AS 15 WK. USING CHROMATOGRAPHIC TECHNIQUES, 2 OF THE COMPOUNDS WERE IDENTIFIED AS THE CORRESPONDING SULFOXIDE & SULFONE.

来源:Hazardous Substances Data Bank (HSDB)

代谢

... /已经证实/，杀螟硫磷的同分异构体转化成更具抑制乙酰胆碱酯酶活性的氧化产物，比母体化合物更有效。

... /IT WAS/ SHOWN THAT THE ISOMERS /OF DEMETON/ ARE CONVERTED TO OXIDN PRODUCTS THAT ARE MORE POTENT INHIBITORS OF ACETYLCHOLINESTERASE THAN PARENT CMPD.

来源:Hazardous Substances Data Bank (HSDB)

代谢

这项研究表明，将杀螟硫磷中的乙硫基乙基部分和P-O异构体的巯基硫氧化成相应的亚砜，最终形成磺酰亚胺，这是杀螟硫磷的重要代谢途径。

Studies in mice are consistent with the notion that oxidation of the mercapto sulfur of the ethylmercaptoethyl portion of demeton and the P-O isomer to the corresponding sulfoxide and finally to the sulfone is an important metabolic pathway for demeton.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 暴露途径

该物质可以通过吸入其气溶胶、通过皮肤和经口摄入被身体吸收。

The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

毒理性

• 暴露途径

吸入，皮肤吸收，吞食，皮肤和/或眼睛接触

inhalation, skin absorption, ingestion, skin and/or eye contact

来源:The National Institute for Occupational Safety and Health (NIOSH)

毒理性

• 症状

眼部刺激，皮肤刺激；瞳孔缩小，眼睛疼痛，流鼻涕（流出稀薄的鼻粘液），头痛；胸闷，喘息，喉部痉挛，流涎，发绀；厌食，恶心，呕吐，腹部绞痛，腹泻；局部出汗；肌肉颤搐，乏力（虚弱，疲惫），瘫痪；头晕，混乱，共济失调；抽搐，昏迷；低血压；心脏不规则

irritation eyes, skin; miosis, ache eyes, rhinorrhea (discharge of thin nasal mucus), headache; chest tightness, wheezing, laryngeal spasm, salivation, cyanosis; anorexia, nausea, vomiting, abdominal cramps, diarrhea; localized sweating; muscle fasciculation, lassitude (weakness, exhaustion), paralysis; dizziness, confusion, ataxia; convulsions, coma; low blood pressure; cardiac irreg

来源:The National Institute for Occupational Safety and Health (NIOSH)

毒理性

• 吸入症状

抽搐。眩晕。呼吸困难。恶心。呕吐。瞳孔收缩，肌肉痉挛，过度流涎。出汗。昏迷。

Convulsions. Dizziness. Laboured breathing. Nausea. Vomiting. Pupillary constriction, muscle cramp, excessive salivation. Sweating. Unconsciousness.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

毒理性

• 皮肤症状

可能会被吸收！进一步请见吸入部分。

MAY BE ABSORBED! Further see Inhalation.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

吸收、分配和排泄

施用DEMETON-S后14天内，这种异构体在棉叶中迅速积累。随后，磺酰氧化物类似物的数量更多。还观察到一些磺酰亚胺。/DEMETON-S/

UP TO 14 DAYS AFTER TOPICAL APPLICATION OF DEMETON-S TO COTTON, THIS ISOMER ACCUMULATED RAPIDLY IN LEAVES. SUBSEQUENTLY, THE SULFOXIDE ANALOG APPEARED IN GREATER QUANTITY. SOME SULFONE WAS ALSO OBSERVED. /DEMETON-S/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

与小鼠一起使用时，管理剂量被迅速吸收、代谢和消除。1-2小时后，胃里只找到了6%或更少的剂量；4小时后，它几乎完全从这些组织中消失。少量通过肠道，但大部分通过尿液而不是粪便排出。

WITH MICE, ADMIN DOSE WAS RAPIDLY ABSORBED, METABOLIZED & ELIMINATED. ONLY 6% OR LESS WAS FOUND IN STOMACH AFTER 1-2 HR; AFTER 4 HR IT HAD ALMOST ENTIRELY DISAPPEARED FROM THESE TISSUES. SMALL AMT PASSED THROUGH INTESTINES BUT MOST WAS ELIMINATED IN URINE RATHER THAN FECES.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

吸收可能通过吸入蒸汽、皮肤吸收或摄入液体发生。

... Absorption may occur from inhalation of the vapor, by skin absorption, or by ingestion of the liquid.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

/敌百虫是一种/ 系统性杀虫剂，即，在树液中转移到植物的所有部位。

/DEMETON IS/ A SYSTEMIC INSECTICIDE, IE, TRANSLOCATED IN SAP TO ALL PARTS OF PLANTS.

来源:Hazardous Substances Data Bank (HSDB)

制备方法与用途

制备方法

由硫代磷酰氯与羟基乙硫醚反应而得。

合成制备方法

同样是由硫代磷酰氯与羟基乙硫醚反应而得。

用途简介

主要用来防治棉花和果树的蚜虫、红蜘蛛等刺吸口器害虫，或用涂茎法防治高粱蚜虫。使用50%乳油3000倍液喷雾，每公顷用量为0.2-0.6kg，可有效防治棉花蚜虫、红蜘蛛、叶蝉、盲蝽象、蓟马等；也能用于防治果树蚜虫、红蜘蛛、梨实蜂、柑桔苗木潜叶蛾，药效一般能维持2-4星期。乳油的150-200倍液涂茎可有效防治高粱蚜虫。使用乳油的10-20倍液包扎树干，则可以防治柑桔蚜虫、锈壁虱、介壳虫。具体用量根据树龄大小，一般每株注入药液约100ml。

用途

主要用来防治棉花和果树的蚜虫、红蜘蛛等刺吸口器害虫，或用涂茎法防治高粱蚜虫。使用50%乳油3000倍液喷雾，每公顷用量为0.2-0.6kg，可有效防治棉花蚜虫、红蜘蛛、叶蝉、盲蝽象、蓟马等；也能用于防治果树蚜虫、红蜘蛛、梨实蜂、柑桔苗木潜叶蛾，药效一般能维持2-4星期。乳油的150-200倍液涂茎可有效防治高粱蚜虫。使用乳油的10-20倍液包扎树干，则可以防治柑桔蚜虫、锈壁虱、介壳虫。具体用量根据树龄大小，一般每株注入药液约100ml。

文献信息

• [EN] MICROBIOCIDAL OXADIAZOLE DERIVATIVES<br/>[FR] DÉRIVÉS D'OXADIAZOLE MICROBIOCIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2017157962A1

  公开（公告）日：2017-09-21

  Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially fungicides.

  式(I)的化合物，其中取代基如权利要求1所定义，作为杀虫剂特别是杀菌剂有用。
• Thieno-pyrimidine compounds having fungicidal activity
  申请人：Brewster Kirkland William

  公开号：US20070093498A1

  公开（公告）日：2007-04-26

  The present invention relates to thieno[2,3-d]-pyrimidine compounds having fungicidal activity.

  本发明涉及具有杀真菌活性的噻吩[2,3-d]-嘧啶化合物。
• [EN] INSECTICIDAL TRIAZINONE DERIVATIVES<br/>[FR] DÉRIVÉS DE TRIAZINONE INSECTICIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2013079350A1

  公开（公告）日：2013-06-06

  Compounds of the formula (I) or (I'), wherein the substituents are as defined in claim 1, are useful as pesticides.

  式(I)或(I')的化合物，其中取代基如权利要求1所定义的那样，可用作杀虫剂。
• [EN] ISOXAZOLINE DERIVATIVES AS INSECTICIDES<br/>[FR] DÉRIVÉS D'ISOXAZOLINE EN TANT QU'INSECTICIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2011101402A1

  公开（公告）日：2011-08-25

  The present invention relates to compounds formula (I), wherein P is P1, P2, heterocyclyl or heterocyclyl substituted by one to five Z; and wherein A1, A2, A3, A4, G1, R1, R2, R3, R4, R5, R6, R17, R18, R19 and R20 are as defined in claim 1; or a salt or N-oxide thereof. Furthermore, the present invention relates to processes and intermediates for preparing compounds of formula (I), to insecticidal, acaricidal, nematicidal and molluscicidal compositions comprising the compounds of formula (I) and to methods of using the compounds of formula (I) to control insect, acarine, nematode and mollusc pests.

  本发明涉及化合物式（I），其中P为P1、P2、杂环烷基或被一到五个Z取代的杂环烷基；以及其中A1、A2、A3、A4、G1、R1、R2、R3、R4、R5、R6、R17、R18、R19和R20如权利要求1中所定义；或其盐或N-氧化物。此外，本发明涉及制备化合物式（I）的过程和中间体，包括化合物式（I）的杀虫剂、杀螨剂、杀线虫剂和杀软体动物剂组合物，以及使用化合物式（I）控制昆虫、螨虫、线虫和软体动物害虫的方法。
• ISOXAZOLINE DERIVATIVES AS INSECTICIDES
  申请人：Pitterna Thomas

  公开号：US20120316124A1

  公开（公告）日：2012-12-13

  The present invention relates to compounds formula (I), wherein P is P1, P2, heterocyclyl or heterocyclyl substituted by one to five Z; and wherein A 1 , A 2 , A 3 , A 4 , G 1 , R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 17 , R 18 , R 19 and R 20 are as defined in claim 1 ; or a salt or N-oxide thereof. Furthermore, the present invention relates to processes and intermediates for preparing compounds of formula (I), to insecticidal, acaricidal, nematicidal and molluscicidal compositions comprising the compounds of formula (I) and to methods of using the compounds of formula (I) to control insect, acarine, nematode and mollusc pests.

  本发明涉及化合物式（I），其中P为P1、P2、杂环烷基或被1至5个Z取代的杂环烷基；以及其中A1、A2、A3、A4、G1、R1、R2、R3、R4、R5、R6、R17、R18、R19和R20如权利要求1所定义；或其盐或N-氧化物。此外，本发明涉及制备化合物式（I）的过程和中间体，包括化合物式（I）的杀虫剂、杀螨剂、杀线虫剂和杀软体动物剂组合物，以及使用化合物式（I）控制昆虫、螨虫、线虫和软体动物害虫的方法。