N-benzylisochroman-1-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: N-benzylisochroman-1-carboxamide
• 英文别名: N-benzyl-3,4-dihydro-1H-isochromene-1-carboxamide
• 化学式: C₁₇H₁₇NO₂
• 分子量: 267.327
• InChiKey: WJVUFIGGUFQLKW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  苄异腈 、 1-甲氧基异苯并二氢吡喃 在 苯膦酸 作用下， 以 乙腈 为溶剂， 反应 24.0h， 以75%的产率得到N-benzylisochroman-1-carboxamide
  参考文献：
  名称：

  Phenylphosphinic Acid-Promoted Addition of Isocyanide to 1-Methoxyisochroman Derivatives

  摘要：

  A synthetic method for preparation of isochroman-1-carboxylamides in good to high yields by addition of isocyanides to 1-methoxyisochroman derivatives in the presence of phosphinic acid was developed. A wide range of 1-methoxyisochroman derivatives and isocyanides were suitable for this reaction.

  DOI：

  10.3987/com-18-s(t)23

文献信息

• Phenylphosphinic Acid-Promoted Addition of Isocyanide to 1-Methoxyisochroman Derivatives
  作者：Takahiro Soeta、Yutaka Ukaji、Syunsuke Matsuzaki

  DOI：10.3987/com-18-s(t)23

  日期：——

  A synthetic method for preparation of isochroman-1-carboxylamides in good to high yields by addition of isocyanides to 1-methoxyisochroman derivatives in the presence of phosphinic acid was developed. A wide range of 1-methoxyisochroman derivatives and isocyanides were suitable for this reaction.