N-(3-methyl-butyl)-thioacetamide

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫代酰胺
• 英文名称: N-(3-methyl-butyl)-thioacetamide
• 英文别名: N-isopentyl-thioacetamide；N-Isopentyl-thioacetamid；N-Isoamyl-thioacetamid；Thioacetyl-isoamylamin；N-(3-methylbutyl)ethanethioamide
• 化学式: C₇H₁₅NS
• mdl: MFCD19222438
• 分子量: 145.269
• InChiKey: GBZDRNDFQJGVPL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.857
• 拓扑面积：
  44.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  异戊胺 、 硫代乙酰胺 在 三氯化锑 作用下， 以 甲苯 为溶剂， 反应 3.5h， 以89%的产率得到N-(3-methyl-butyl)-thioacetamide
  参考文献：
  名称：

  Transamidation of thioacetamide catalyzed by SbCl3

  摘要：

  A transamidation reaction of thioacetamide with primary and secondary amines is described. The use of catalytic amounts of SbCl3 notably increases the yields and diminishes the reaction times. Typically, the amines should be aliphatic, but aromatic amines can be used as well, though with lower yields. This is one of the few examples where antimony has been used as a catalyst in organic reactions. (c) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.05.067

文献信息

• Sakurada, Bulletin of the Chemical Society of Japan, 1927, vol. 2, p. 308
  作者：Sakurada

  DOI：——

  日期：——
• Transamidation of thioacetamide catalyzed by SbCl3
  作者：Andrea Ojeda-Porras、Diego Gamba-Sánchez

  DOI：10.1016/j.tetlet.2015.05.067

  日期：2015.7

  A transamidation reaction of thioacetamide with primary and secondary amines is described. The use of catalytic amounts of SbCl3 notably increases the yields and diminishes the reaction times. Typically, the amines should be aliphatic, but aromatic amines can be used as well, though with lower yields. This is one of the few examples where antimony has been used as a catalyst in organic reactions. (c) 2015 Elsevier Ltd. All rights reserved.