2-methyl-1-(5-methylthiophen-2-yl)-1H-imidazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: 2-methyl-1-(5-methylthiophen-2-yl)-1H-imidazole
• 英文别名: 2-Methyl-1-(5-methylthiophen-2-yl)imidazole；2-methyl-1-(5-methylthiophen-2-yl)imidazole
• 化学式: C₉H₁₀N₂S
• 分子量: 178.258
• InChiKey: PCXYWGVNCAELTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  46.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-溴-5-甲基噻吩 、 2-甲基咪唑 在 copper(l) iodide [bmim]BF₄ 、 potassium carbonate 、 L-脯氨酸 作用下， 反应 48.0h， 以46%的产率得到2-methyl-1-(5-methylthiophen-2-yl)-1H-imidazole
  参考文献：
  名称：

  CuI catalyzed C–N bond forming reactions between aryl/heteroaryl bromides and imidazoles in [Bmim]BF4

  摘要：

  By using CuI as the catalyst and L-Proline as the ligand, the Ullmann-type coupling reactions of aryl/heteroaryl bromides and imidazoles in [Bmim]BF4 at 105-115 degrees C gave the corresponding N-arylimidazoles/N-heteroarylimidazoles in good yields. The system offers a convenient, recyclable, and environmentally benign method for these coupling reactions. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.03.026

文献信息

• Novel Pyrrole Inhibitors of S-Nitrosoglutathione Reductase as Therapeutic Agents
  申请人：N30 Pharmaceuticals, Inc.

  公开号：US20150126570A1

  公开（公告）日：2015-05-07

  The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same.

  本发明涉及S-亚硝基谷胱甘肽还原酶（GSNOR）抑制剂、包含此类GSNOR抑制剂的药物组合物以及制备和使用它们的方法。
• US9180119B2
  申请人：——

  公开号：US9180119B2

  公开（公告）日：2015-11-10
• CuI catalyzed C–N bond forming reactions between aryl/heteroaryl bromides and imidazoles in [Bmim]BF4
  作者：Xin Lv、Zhiming Wang、Weiliang Bao

  DOI：10.1016/j.tet.2006.03.026

  日期：2006.5

  By using CuI as the catalyst and L-Proline as the ligand, the Ullmann-type coupling reactions of aryl/heteroaryl bromides and imidazoles in [Bmim]BF4 at 105-115 degrees C gave the corresponding N-arylimidazoles/N-heteroarylimidazoles in good yields. The system offers a convenient, recyclable, and environmentally benign method for these coupling reactions. (c) 2006 Elsevier Ltd. All rights reserved.