(R)-1-(1-phenyl-3-(trimethylsilyl)prop-2-ynyl)piperidin-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (R)-1-(1-phenyl-3-(trimethylsilyl)prop-2-ynyl)piperidin-4-one
• 英文别名: (R)-1-(4-methyl-1-phenylpent-1-yn-3-yl)piperidin-4-one；1-[(3R)-4-methyl-1-phenylpent-1-yn-3-yl]piperidin-4-one
• 化学式: C₁₇H₂₁NO
• 分子量: 255.36
• InChiKey: NXMVBRICEOEFJE-KRWDZBQOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-氧代哌啶酮盐酸盐 、 异丁醛 、 苯乙炔 在 (-)-2-(2-(diphenylphosphino)naphthalen-1-yl)-1-(perfluorobenzyl)-4,5-diphenyl-1H-imidazole 、 三乙胺 、 copper(I) bromide 作用下， 以 二氯甲烷 为溶剂， 以80%的产率得到(R)-1-(1-phenyl-3-(trimethylsilyl)prop-2-ynyl)piperidin-4-one
  参考文献：
  名称：

  [EN] BIARYL LIGANDS
  [FR] LIGANDS BIARYLE

  摘要：

  本公开的实施例提供了联苯配体（在本文中也称为“联苯化合物”）、联苯配合物的制备方法、制备这些联苯化合物的单对映体的方法、使用方法（例如催化）等。

  公开号：

  WO2015038872A1

文献信息

• Biaryl ligands, methods of making biarlyl ligands, and methods of use thereof
  申请人：University of Florida Research Foundation, Inc.

  公开号：US11198701B2

  公开（公告）日：2021-12-14

  Embodiments of the present disclosure provide for biaryl ligands (also referred to herein as “biaryl compound”), biaryl complexes, methods of making biaryl compounds, methods of making single enantiomers of these biaryl compounds, methods of use (e.g., catalysis), and the like.

  本公开的实施方案提供了双芳基配体（此处也称为 "双芳基化合物"）、双芳基络合物、双芳基化合物的制造方法、这些双芳基化合物的单一对映体的制造方法、使用方法（例如催化）等。
• Design, Preparation, and Implementation of an Imidazole-Based Chiral Biaryl P,N-Ligand for Asymmetric Catalysis
  作者：Flavio S. P. Cardoso、Khalil A. Abboud、Aaron Aponick

  DOI：10.1021/ja407689a

  日期：2013.10.2

  A new strategy for increasing the barrier to rotation in biaryls has been developed that allows for the incorporation of 5-membered aromatic heterocycles into chiral atropisomers. Using this concept, an imidazole-based biaryl P,N-ligand has been designed and prepared as a single enantiomer. This ligand perfonns exceptionally well in the enantioselective A(3)-coupling, demonstrating the potential of this new design element.
• Highly Enantioselective Access to Primary Propargylamines:  4-Piperidinone as a Convenient Protecting Group
  作者：Patrick Aschwanden、Corey R. J. Stephenson、Erick M. Carreira

  DOI：10.1021/ol060876w

  日期：2006.5.1

  [graphics]We report a highly enantioselective, catalytic three-component coupling of aldehydes, alkynes, and 4-piperidone hydrochloride hydrate to afford the corresponding tertiary propargylamines in useful yields. The selective cleavage of the piperidone protecting group using either ammonia/EtOH or a polymer-supported scavenger amine furnishes primary propargylamines.
• BIARYL LIGANDS
  申请人：THE UNIVERSITY OF FLORIDA RESEARCH FOUNDATION INC.

  公开号：US20160222041A1

  公开（公告）日：2016-08-04

  Embodiments of the present disclosure provide for biaryl ligands (also referred to herein as “biaryl compound”), biaryl complexes, methods of making biaryl compounds, methods of making single enantiomers of these biaryl compounds, methods of use (e.g., catalysis) and the like.
• BIARYL LIGANDS, METHODS OF MAKING BIARLYL LIGANDS, AND METHODS OF USE THEREOF
  申请人：University of Florida Research Foundation, Inc.

  公开号：US20200223878A1

  公开（公告）日：2020-07-16

  Embodiments of the present disclosure provide for biaryl ligands (also referred to herein as “biaryl compound”), biaryl complexes, methods of making biaryl compounds, methods of making single enantiomers of these biaryl compounds, methods of use (e.g., catalysis), and the like.