4-(naphthalen-1-yloxy)-1-nitronaphthalene

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-(naphthalen-1-yloxy)-1-nitronaphthalene
• 英文别名: 1-Naphthalen-1-yloxy-4-nitronaphthalene；1-naphthalen-1-yloxy-4-nitronaphthalene
• 化学式: C₂₀H₁₃NO₃
• 分子量: 315.328
• InChiKey: VKQCBDKVXCOAOE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  55
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  萘酚 、 1-氟-4-硝基萘 在 2-叔丁基-1,1,3,3-四甲基胍 作用下， 以 乙腈 为溶剂， 反应 1.0h， 以88%的产率得到4-(naphthalen-1-yloxy)-1-nitronaphthalene
  参考文献：
  名称：

  Synthesis of Highly Oxygenated Dinaphthyl Ethers via S_NAr Reactions Promoted by Barton's Base

  摘要：

  [GRAPHIC]Electron-rich dinaphthyl ethers were synthesized by SNAr reactions between naphthols and activated fluoronaphthalenes. 2-tert-Butyl-1,1,3,3-tetramethylguanidine (Barton's base) was found to be an excellent, mild alternative to traditional inorganic bases for promoting the coupling reaction.

  DOI：

  10.1021/ol034286z

文献信息

• Synthesis of Highly Oxygenated Dinaphthyl Ethers via S_NAr Reactions Promoted by Barton's Base
  作者：Peter Wipf、Stephen M. Lynch

  DOI：10.1021/ol034286z

  日期：2003.4.1

  [GRAPHIC]Electron-rich dinaphthyl ethers were synthesized by SNAr reactions between naphthols and activated fluoronaphthalenes. 2-tert-Butyl-1,1,3,3-tetramethylguanidine (Barton's base) was found to be an excellent, mild alternative to traditional inorganic bases for promoting the coupling reaction.