(+)(3R,4R)-4-benzyl-1-[2-(4-hydroxy-benzenesulfonyl)-ethyl]-piperidin-3-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (+)(3R,4R)-4-benzyl-1-[2-(4-hydroxy-benzenesulfonyl)-ethyl]-piperidin-3-ol
• 英文别名: (3R,4R)-4-benzyl-1-[2-(4-hydroxy-benzenesulfonyl)-ethyl]-piperidin-3-ol；(3R,4R)-4-benzyl-1-[2-(4-hydroxyphenyl)sulfonylethyl]piperidin-3-ol
• 化学式: C₂₀H₂₅NO₄S
• 分子量: 375.489
• InChiKey: UDLDPIPQVZOCPK-PXNSSMCTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  86.2
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-羟基苯硫酚 在 sodium hydroxide 、 氯化亚砜 、 氯 作用下， 以 吡啶 、 甲醇 、 CH₂- 、 二氯甲烷 、 乙酸乙酯 为溶剂， 生成 (+)(3R,4R)-4-benzyl-1-[2-(4-hydroxy-benzenesulfonyl)-ethyl]-piperidin-3-ol
  参考文献：
  名称：

  Ethanesulfonyl-piperidine derivatives

  摘要：

  本发明涉及一般式化合物，其中R1表示氢或羟基；R2表示氢或甲基；X表示—O—或—CH2—及其药学上可接受的酸加盐。已经证明这些化合物与NMDA受体有很好的亲和力，因此它们在治疗疾病方面非常有用，其中治疗指标包括急性神经退化的形式，例如中风或脑外伤引起的急性神经退化；慢性神经退化，如阿尔茨海默病、帕金森病、亨廷顿病或ALS（肌萎缩侧索硬化症）；与细菌或病毒感染相关的神经退化，以及精神分裂症、焦虑、抑郁和慢性/急性疼痛等疾病。

  公开号：

  US06310213B1

文献信息

• Anti-reflection optical article and process of producing the same
  申请人：TORAY INDUSTRIES, INC.

  公开号：EP0278060A2

  公开（公告）日：1988-08-17

  Disclosed is an anti-reflection optical article which has an excellent anti-reflection property, scratch resistance, impact resistance, flexibility, anti-static property and weatherability, and which is easy to dye. The anti-reflection optical article of the present invention comprises a transparent plastic substrate; a hard coat film formed on a surface of the substrate, the film having an index of refraction of not less than 1.52; and a fluorine-containing organopolysiloxane-based film with a thickness of 10 nm to 500 nm, which has an index of refraction lower than that of the hard coat film by not less than 0.02, and which is formed on the hard coat film.

  本发明公开了一种抗反射光学制品，它具有优异的抗反射性、抗划伤性、抗冲击性、柔韧性、抗静电性和耐候性，并且易于染色。本发明的抗反射光学制品包括：透明塑料基板；形成于基板表面的硬涂层薄膜，该薄膜的折射率不小于 1.52；以及形成于硬涂层薄膜上的含氟有机聚硅氧烷基薄膜，其厚度为 10 nm 至 500 nm，该薄膜的折射率比硬涂层薄膜的折射率低不小于 0.02。
• Transparent resin and transparent resin products
  申请人：NIPPON OIL AND FATS COMPANY, LIMITED

  公开号：EP0320954A2

  公开（公告）日：1989-06-21

  A transparent resin is obtained by polymerizing a feed starting material containing at least one monomer represented by the formula (I) wherein R₁- represents -CH=CH₂, CH₂-CH=CH₂, -COOC(CH₃)=CH₂, -COOCH₂-CH=CH₂,-OCOO-CH₂-CH=CH₂, -OCOO-CH₂-C(CH₃)=CH₂, -OCOCH=CH₂ or -OCOC(CH₃)=CH₂, R₂- represents -H, -OCH₃, -SCH₃, -CH₃, -C₂H₅ or -CH=CH₂, and A₁ and A₂ each represent O or S. A transparent optical article is constituted of the transparent resin obtained by polymerizing the monomer of the formula (I). A paint composition comprises the transparent resin obtained by polymerizing the monomer of the formula (I).

  一种透明树脂是通过聚合含有至少一种由式 (I) 表示的单体的原料起始材料而获得的 其中 R₁- 代表-CH=CH₂、CH₂-CH=CH₂、-COOC(CH₃)=CH₂、-COOCH₂-CH=CH₂、-OCOO-CH₂-CH=CH₂、-OCOO-CH₂-C(CH₃)=CH₂、-OCOCH=CH₂或-OCOC(CH₃)=CH₂，R₂-代表-H、-OCH₃、-SCH₃、-CH₃、-C₂H₅或-CH=CH₂，A₁和A₂各自代表O或S。透明光学制品由通过聚合式 (I) 单体得到的透明树脂构成。涂料组合物由通过聚合式（I）单体得到的透明树脂构成。
• Transparent resin and plastic lens
  申请人：HITACHI CHEMICAL CO., LTD.

  公开号：EP0661307A2

  公开（公告）日：1995-07-05

  A transparent resin obtained by polymerizing a monomer having an alkylene oxide group, a polyfunctional (meth)acrylate having a divalent branched hydrocarbon group and other copolymerizable vinyl monomer, if necessary, is suitable as an elementary material for a plastic lens with excellent heat resistance and hue.

  通过聚合具有环氧亚烷基的单体、具有二价支链烃基的多官能（甲基）丙烯酸酯和其他可共聚的乙烯基单体（如有必要）而得到的透明树脂，适合作为塑料镜片的基本材料，具有优异的耐热性和色调。
• COATING COMPOSITION AND METHOD FOR PREPARATION THEREOF
  申请人：TOKUYAMA CORPORATION

  公开号：EP1153998A1

  公开（公告）日：2001-11-14

  A highly refractive coating composition which can be stably preserved without losing the initial properties even after preserved for extended periods of time. The coating composition contains a metal oxide, a polymerizable alkoxysilane compound, a polymerization catalyst, an acidic aqueous solution and a solvent, wherein an organoamine compound is contained in an amount of from 0.05 to 1.3% by weight with respect to the metal oxide. A method of producing the coating composition comprises mixing a metal oxide suspension containing an organoamine compound in an amount of not smaller than 1.3% by weight with respect to the metal oxide, a polymerizable alkoxysilane compound, a polymerization catalyst, an acidic aqueous solution and a solvent, wherein the organoamine compound is removed so that the amount thereof is from 0.05 to 1.3% by weight with respect to the metal oxide contained in said metal oxide suspension.

  一种高折射率涂层组合物，即使长时间保存也不会失去初始特性。该涂层组合物含有金属氧化物、可聚合烷氧基硅烷化合物、聚合催化剂、酸性水溶液和溶剂，其中有机胺化合物的含量为金属氧化物重量的 0.05% 至 1.3%。一种生产涂层组合物的方法，包括将含有有机胺化合物的金属氧化物悬浮液、可聚合烷氧基硅烷化合物、聚合催化剂、酸性水溶液和溶剂混合，有机胺化合物的含量不小于金属氧化物重量的1.3%，其中有机胺化合物的去除量为所述金属氧化物悬浮液中所含金属氧化物重量的0.05-1.3%。
• CROSSLINKABLE NITRILE RUBBER COMPOSITION AND CROSSLINKED RUBBER PRODUCT
  申请人：Zeon Corporation

  公开号：EP3184585A1

  公开（公告）日：2017-06-28

  A cross-linkable nitrile rubber composition comprising a highly saturated nitrile rubber (A) containing α,β-ethylenically unsaturated nitrile monomer units in a ratio of 10 to 60 wt% and having an iodine value of 120 or less, a master batch (B) containing an ethylene-vinyl acetate copolymer (b1) having a melt flow rate measured under a load of 21.18N at 190°C of 0.5 to 1000 g/10 min. and containing vinyl acetate monomer units in a ratio of 5 to 50 wt% and an organic staple fiber (b2) having an average fiber length of 0.1 to 12 mm, and a cross-linking agent (C), wherein a ratio of the ethylene-vinyl acetate copolymer (b1) and the organic staple fiber (b2) in the master batch (B) is, in terms of a weight ratio of "ethylene-vinyl acetate copolymer (b1) :organic staple fiber (b2)", 30:70 to 80:20 is provided.

  一种可交联丁腈橡胶组合物，包括一种高饱和丁腈橡胶 (A)，其中α,β-乙烯基不饱和丁腈单体单元的比例为 10 至 60 wt%，碘值为 120 或更低；一种母料 (B)，其中乙烯-醋酸乙烯共聚物 (b1)，其在 190°C 时的载荷为 21.18N 的条件下测得的熔体流动速率为 0.5 至 1000 g/10min，其中醋酸乙烯单体单元的比例为 5 至 50 wt%；以及一种有机短纤维 (b2)，其平均纤维长度为 0.乙烯-醋酸乙烯共聚物 (b1)在 190°C、21.18N 载荷下测得的熔体流动速率为 0.5 至 1000 克/10 分钟，其中醋酸乙烯单体单元的比例为 5 至 50 wt%，有机短纤维 (b2) 的平均纤维长度为 0.其中母料 (B) 中乙烯-醋酸乙烯共聚物 (b1) 和有机短纤维 (b2) 的重量比为 "乙烯-醋酸乙烯共聚物 (b1) :有机短纤维 (b2)"，即 30:70 至 80:20。