Ethyl 2-[7-(chloromethyl)naphthalen-1-yl]-2-oxoacetate

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: Ethyl 2-[7-(chloromethyl)naphthalen-1-yl]-2-oxoacetate
• 化学式: C₁₅H₁₃ClO₃
• 分子量: 276.71
• InChiKey: GVHJLIHMQVQNDG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Preparing method of alpha-ketocarboxylic acid derivatives
  申请人：KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

  公开号：EP1097917B1

  公开（公告）日：2003-02-12
• [EN] PREPARING METHOD OF ALPHA-KETOCARBOXYLIC ACID DERIVATIVES<br/>[FR] PREPARATION DE DERIVES D'ACIDE ALPHA-CETOCARBOXYLIQUE
  申请人：KOREA RES INST CHEM TECH

  公开号：WO2001030741A1

  公开（公告）日：2001-05-03

  The present invention relates to a preparing method of α-ketocarboxylic acid derivatives, more specifically to a preparing method of α-ketocarboxylic acid derivatives, expressed by Formula (1) and widely used as major source material for the synthesis of agrochemicals and medicines, by reacting α-hydroxycarboxylic acid derivatives with hypobromous acid (HOBr). In Formula (1), R1 represents hydrogen atom, C1∩C10alkyl, C1∩C10haloalkyl, C1∩C10alkoxyalkyl, C3∩C6 cycloalkyl or aryl, wherein the said aryl is benzene, naphthalene, pyridine or thiophene with more than one functional groups selected from hydrogen atom, hydroxy, halogen atom, C1∩C3alkyl, -(CH2)mL, C1∩C3alkoxy, phenoxy and nitro group, wherein the said L is halogen atom, alkylsulphonyloxy, benzenesulfonyloxy or toluenesulfonyl oxy group, and the said m is the integer number of 1 or 2; R2 represents hydrogen atom or C1∩C6alkyl; and n represents 0 or integer number of 1∩10.