8-nitro-7-oxo-6aH-1,10-phenanthroline-3-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 菲咯啉
• 英文名称: 8-nitro-7-oxo-6aH-1,10-phenanthroline-3-carboxylic acid
• 化学式: C13H7N3O5
• 分子量: 285.21
• InChiKey: JHTPBEQAUGVMGF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  125
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Hif Modulating Compounds and Methods of Use Thereof
  申请人：Johnson Randall S.

  公开号：US20080213404A1

  公开（公告）日：2008-09-04

  A method is provided for treating subjects, including humans, with infection or virulence by pathogens. The method involves administering an agent in amounts effective to eradicate or reduce infections and/or an inflammatory response caused by pathogens. Methods for identifying compounds useful as anti-infectives that decrease the immune resistance, virulence, or growth of microbes are also provided. More particularly, there are provided methods for identifying compounds which increase accumulation or stability or activity, or alternatively decrease the degradation of HIF-1a protein.