3-methoxy-6-[(4S,5S)-5-(3,4,5-trimethoxyphenyl)-1,3-dioxolan-4-yl]benzene-1,2-diol

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 3-methoxy-6-[(4S,5S)-5-(3,4,5-trimethoxyphenyl)-1,3-dioxolan-4-yl]benzene-1,2-diol
• 化学式: C₁₉H₂₂O₈
• 分子量: 378.4
• InChiKey: BINDBONFGUETJQ-ROUUACIJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  95.8
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Hydroxyphenstatin and the prodrugs thereof
  申请人：——

  公开号：US20030220304A1

  公开（公告）日：2003-11-27

  The benzophenone derivative of combretastatin A-1, designated “hydroxyphenstatin”, was synthesized by compiling a protected bromobenzene and a benzaldehyde to form a benzhydrol which was subsequently oxidized to the ketone. Hydroxyphenstatin was converted to a sodium phosphate prodrug by dibenzyl phosphite phosphorylation and subsequent benzyl cleavage: Hydroxyphenstatin and the prodrugs thereof were found to be a potent inhibitor of tubulin polymerization and to demonstrate surprisingly effective anti neoplastic activity against a series of human cancer cells and murine P388 lymphocytic leukemia cells.

  将康柏乙烯A-1的苯甲酮衍生物命名为“羟基苯基苯甲酮”，通过组合保护溴苯和苯甲醛合成苯并醇，随后氧化为酮。通过二苯基磷酸酯磷酸化和随后的苄基裂解，将羟基苯基苯甲酮转化为磷酸钠前药。发现羟基苯基苯甲酮及其前药是强效的微管聚合抑制剂，并对一系列人类癌细胞和小鼠P388淋巴细胞白血病细胞表现出惊人的有效抗肿瘤活性。
• Antitubulin assembly and cell growth inhibitor denominated "dioxostatin"
  申请人：——

  公开号：US20040122083A1

  公开（公告）日：2004-06-24

  A new inhibitor of microtubule assembly (IC 50 0.59 &mgr;M); with antineoplastic properties, denominated “dioxostatin”, has been synthesized and its effectiveness against human cancer and murine P388 lymphocytic leukemia cell lines demonstrated. Dioxostatin hs the following structure (I). 1

  一种新的微管聚集抑制剂（IC500.59μM），具有抗肿瘤性能，被称为“二氧基斯他汀”已经合成，并在人类癌症和小鼠P388淋巴细胞白血病细胞系中展示了其有效性。二氧基斯他汀的结构如下（I）。
• ANTITUBULIN ASSEMBLY AND CELL GROWTH INHIBITOR DENOMINATED "DIOXOSTATIN"
  申请人：Arizona Board of Regents, acting for and on behalf of Arizona State University

  公开号：EP1283672B1

  公开（公告）日：2004-11-17
• US6777578B2
  申请人：——

  公开号：US6777578B2

  公开（公告）日：2004-08-17