4-(3-{7-[2-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-oxoethyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}-2-hydroxypropoxy)benzonitrile | 335619-40-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并二恶烷
• 英文名称: 4-(3-{7-[2-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-oxoethyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}-2-hydroxypropoxy)benzonitrile
• 英文别名: 4-[3-[7-[2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2-oxoethyl]-9-oxa-3,7-diazabicyclo[3.3.1]nonan-3-yl]-2-hydroxypropoxy]benzonitrile
• CAS: 335619-40-4
• 化学式: C₂₆H₂₉N₃O₆
• 分子量: 479.533
• InChiKey: CVSUYSPEMPQIJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  35
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  105
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• [EN] PHARMACEUTICAL COMBINATION<br/>[FR] COMBINAISON PHARMACEUTIQUE
  申请人：ASTRAZENECA AB

  公开号：WO2003101956A1

  公开（公告）日：2003-12-11

  There is provided a combination product comprising: (1) a compound of claim 1 in WO 02/44145 or a compound of claim 20 in WO 02/44145 (or derivative thereof)or a pharmaceutically-acceptable derivative thereof; and (1) a compound as defined in claim 1 of WO 01/28992 or (2) a compound of Claim 34 of WO 01/28992 or (3) Compound A or B or C or D (or pharmaceutically-acceptable salts thereof) for use in treating arrhythmia or a coagulation controlled complication thereof.

  提供了一种组合产品，包括：(1) WO 02/44145中权利要求1的化合物或WO 02/44145中权利要求20的化合物（或其衍生物）或药用可接受的衍生物；以及（1）WO 01/28992中权利要求1定义的化合物或（2）WO 01/28992中权利要求34的化合物或（3）化合物A或B或C或D（或药用可接受的盐）用于治疗心律不齐或其凝血控制的并发症。
• New oxabispidine compounds useful in the treatment of cardiac arrhythmias
  申请人：Bjore Annika

  公开号：US20060166979A1

  公开（公告）日：2006-07-27

  There is provided compounds of formula I, wherein R 1 , R 2 , R 3 , R 4 , R 41 to R 46 , A, B and G have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.

  提供了公式I的化合物，其中R1、R2、R3、R4、R41到R46、A、B和G在描述中给出了它们的含义，这些化合物在预防和治疗心律失常方面有用，特别是房性和室性心律失常。
• Pharmaceutical combination
  申请人：Roth-Rosendahl Ann-Charlotte

  公开号：US20060052314A1

  公开（公告）日：2006-03-09

  There is provided a combination product comprising: (1) a compound of claim 1 in WO 02/44145 or a compound of claim 20 in WO 02/44145 (or derivateive thereof) or a pharmaceutically-acceptable derivative thereof; and (1) a compound as defined in claim 1 or WO 01/28993 or (2) compound of claim 34 or WO 01/28992 or (3) Compound A or B or C or D (or pharmaceutically-acceptable salts therof) for use in treating arrhythmia or a coagulation controlled complicaiton thereof.

  提供了一种组合产品，包括：（1）WO 02/44145中权利要求1的化合物或权利要求20的化合物（或其衍生物）或其药学上可接受的衍生物；和（2）权利要求1或WO 01/28993中定义的化合物或（3）权利要求34或WO 01/28992中的化合物A或B或C或D（或其药学上可接受的盐），用于治疗心律失常或其凝血控制并发症。
• Oxabispidine compounds useful in the treatment of cardiac arrhythmias
  申请人：Bjore Annika

  公开号：US20070117799A1

  公开（公告）日：2007-05-24

  There is provided compounds of formula I, wherein R 1 , R 2 , R 3 , R 4 , R 41 to R 46 , A, B and G have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.

  提供了式I的化合物，其中R1、R2、R3、R4、R41至R46、A、B和G的含义在说明中给出，这些化合物在预防和治疗心律失常，特别是心房和心室心律失常方面是有用的。
• New oxabispidine compunds useful in the treatment of cardiac arrhythmias
  申请人：Bjore Annika

  公开号：US20090326221A1

  公开（公告）日：2009-12-31

  There is provided compounds of formula I, wherein R 1 , R 2 , R 3 , R 4 , R 41 to R 46 , A, B and G have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.

  提供了I式化合物，其中R1、R2、R3、R4、R41至R46、A、B和G具有描述中给出的含义，这些化合物在预防和治疗心律失常，特别是房颤和室性心律失常方面具有用途。