2-[4-[(Z)-4-chloro-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine;2-[4-[(Z)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 2-[4-[(Z)-4-chloro-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine;2-[4-[(Z)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine
• 化学式: C52H57ClN2O2
• 分子量: 777.5
• InChiKey: ZHNAWHXBPOGUIH-MPHYBFPFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.21
• 重原子数：
  57
• 可旋转键数：
  17
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  24.9
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• NOVEL ESTROGEN RECEPTOR MUTATIONS AND USES THEREOF
  申请人：FOUNDATION MEDICINE, INC.

  公开号：US20180320238A1

  公开（公告）日：2018-11-08

  Novel mutant ESR1 molecules and uses are disclosed.
• [EN] MULTIFUNCTIONAL RNA NANOPARTICLES AND METHODS FOR TREATING CANCER AND THERAPEUTIC RESISTANT CANCER<br/>[FR] NANOPARTICULES D'ARN MULTIFONCTIONNELLES ET PROCÉDÉS DE TRAITEMENT DU CANCER ET D'UN CANCER RÉSISTANT À UNE THÉRAPIE
  申请人：UNIV CINCINNATI

  公开号：WO2018106992A1

  公开（公告）日：2018-06-14

  RNA nanoparticles functionalized with a HER2-targeting RNA aptamer and at least one MED1 siRNA for targeted delivery of MED1 siRNA to human cancer cells via human epidermal growth factor receptor 2 (HER2) receptors, pharmaceutical compositions of the inventive RNA nanoparticles, and methods for treating breast, HER2-implicated cancers, and in particular therapeutic-resistant cancer such as tamoxifen-resistant breast cancer, by administering pharmaceutical compositions of the inventive RNA nanoparticles.