(2S)-6,8-dichloro-2-(trifluoromethyl)-2H-chromene-3-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: (2S)-6,8-dichloro-2-(trifluoromethyl)-2H-chromene-3-carboxamide
• 化学式: C₁₁H₆Cl₂F₃NO₂
• 分子量: 312.07
• InChiKey: PDFDYGQQXRLGOA-VIFPVBQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Method of using a COX-2 inhibitor and a TACE inhibitors as a combination therapy
  申请人：Pharmacia Corporation

  公开号：US20040122011A1

  公开（公告）日：2004-06-24

  The present invention provides compositions and methods to treat, prevent or inhibit a neoplasia, a neoplasia-related disorder, pain, inflammation, an inflammatory-related disorder, a vaso-occlusive event or a vaso-occlusive-related disorder in a mammal using a combination of a COX-2 inhibitor and a TACE inhibitor.

  本发明提供了一种使用COX-2抑制剂和TACE抑制剂的组合物和方法，以治疗、预防或抑制哺乳动物中的肿瘤、肿瘤相关疾病、疼痛、炎症、炎症相关疾病、血管闭塞性事件或血管闭塞性相关疾病。
• Method of using a COX-2 inhibitor and an alkylating-type antineoplastic agent as a combination therapy in the treatment of neoplasia
  申请人：Pharmacia Corporation

  公开号：US20040072889A1

  公开（公告）日：2004-04-15

  The present invention provides compositions and methods to treat, prevent or inhibit a neoplasia or a neoplasia-related disorder in a mammal using a combination of a COX-2 inhibitor and an alkylating-type antineoplastic agent.

  本发明提供了一种使用COX-2抑制剂和烷基化类抗肿瘤药物的组合来治疗、预防或抑制哺乳动物中的肿瘤或与肿瘤相关的疾病的组合物和方法。
• Method of using COX-2 inhibitors in the treatment and prevention of ocular COX-2 mediated disorders
  申请人：——

  公开号：US20020128267A1

  公开（公告）日：2002-09-12

  The present invention provides methods for the treatment and prevention of ocular COX-2 mediated disorders using COX-2 inhibitors.

  本发明提供了使用 COX-2 抑制剂治疗和预防由 COX-2 介导的眼部疾病的方法。
• Method of using a COX-2 inhibitor and a topoisomerase II inhibitor as a combination therapy in the treatment of neoplasia
  申请人：Pharmacia Corporation

  公开号：US20030225150A1

  公开（公告）日：2003-12-04

  The present invention provides compositions and methods to treat, prevent or inhibit a neoplasia or a neoplasia-related disorder in a mammal using a combination of a COX-2 inhibitor and a topoisomerase II inhibitor.

  本发明提供了使用 COX-2 抑制剂和拓扑异构酶 II 抑制剂组合治疗、预防或抑制哺乳动物肿瘤或肿瘤相关疾病的组合物和方法。
• Method of using cox-2 inhibitors in the treatment and prevention of ocular cox-2 mediated disorders
  申请人：——

  公开号：US20040058926A1

  公开（公告）日：2004-03-25

  The present invention provides methods for the treatment and prevention of ocular COX-2 mediated disorders using COX-2 inhibitors.

  本发明提供了使用 COX-2 抑制剂治疗和预防由 COX-2 介导的眼部疾病的方法。