4-[4-hydroxy-3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)phenyl]benzoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-[4-hydroxy-3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)phenyl]benzoic acid
• 英文别名: 4-[4-Hydroxy-3-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)phenyl]benzoic acid
• 化学式: C₂₇H₂₈O₃
• 分子量: 400.518
• InChiKey: RVWDVDCJZLLBAZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.5
• 重原子数：
  30
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Biphenyl compound selective agonists of gamma RAR receptors
  申请人：Biadatti Thibaud

  公开号：US20090036536A1

  公开（公告）日：2009-02-05

  Biphenyl compounds having the formula (I): are useful for preventing/treating pathologies linked to a deficiency of the activation of the RAR gamma receptor, e.g., for treating a pathology linked to a cell differentiation and/or proliferation disorder, for treating acne, for treating psoriasis.

  具有以下化学式（I）的二苯基化合物：对于预防/治疗与RAR gamma受体激活不足有关的病理学，例如用于治疗与细胞分化和/或增殖紊乱有关的病理学，用于治疗痤疮和牛皮癣等病理学是有用的。
• Biphenyl derivatives substituted with an aromatic or heteroaromatic radical, and pharmaceutical and cosmetic compositions containing them
  申请人：Galderma Research & Development

  公开号：US20040030141A1

  公开（公告）日：2004-02-12

  Compounds of formula (I): 1 in which: Ar represents an aromatic or a heteroaromatic radical optionally substituted, in particular, with an alkyl or a carboxyl group, R 2 and R 3 represent, in particular, H or alkyl, or R 2 and R 3 , taken together, form a 5- or 6-membered ring, R 4 and R 5 represent, in particular, H or halogen, R 6 represents, in particular, H or lower alkyl, and the salts of the compounds of formula (I). These compounds can be used in particular in the treatment of dermatological complaints associated with a keratinization disorder, and for combating ageing of the skin.

  化合物的公式（I）：其中：Ar代表芳香或杂环基团，可选地取代，特别是用烷基或羧基取代，R2和R3代表特别是氢或烷基，或R2和R3一起形成5或6元环，R4和R5代表特别是氢或卤素，R6代表特别是氢或低烷基，以及化合物的盐。这些化合物可以特别用于治疗与角化障碍相关的皮肤疾病，并用于抗皮肤衰老。
• DERIVES BIPHENYLIQUES SUBSTITUES PAR UN RADICAL AROMATIQUE OU HETEROAROMATIQUE ET COMPOSITIONS PHARMACEUTIQUES ET COSMETIQUES LES CONTENANT
  申请人：Galderma Research & Development

  公开号：EP0952974A1

  公开（公告）日：1999-11-03
• DERIVES BIPHENYLIQUES AGONISTES SELECTIFS DU RECEPTEUR RAR-GAMMA
  申请人：GALDERMA RESEARCH & DEVELOPMENT

  公开号：EP1963250A1

  公开（公告）日：2008-09-03
• US6316009B1
  申请人：——

  公开号：US6316009B1

  公开（公告）日：2001-11-13