BB-78485

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: BB-78485
• 英文别名: (2r)-N-Hydroxy-3-Naphthalen-2-Yl-2-[(Naphthalen-2-Ylsulfonyl)amino]propanamide；(2R)-N-hydroxy-3-naphthalen-2-yl-2-(naphthalen-2-ylsulfonylamino)propanamide
• 化学式: C₂₃H₂₀N₂O₄S
• 分子量: 420.489
• InChiKey: MMOUXLMPQFMDRD-JOCHJYFZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Molecular interaction sites of vimentin RNA and methods of modulating the same
  申请人：——

  公开号：US20030083483A1

  公开（公告）日：2003-05-01

  Methods for the identification of compounds which modulate, either inhibit or stimulate, biomolecules are provided. Nucleic acids, especially RNAs are preferred substrates for such modulation. The present methods are particularly powerful in that they provide novel combinations of techniques which give rise to compounds, usually “small” organic compounds, which are highly potent modulators of RNA and other biomolecular activity. In accordance with preferred aspects of the invention, very large numbers of compounds may be tested essentially simultaneously to determine whether they are likely to interact with a molecular interaction site and modulate the activity of the biomolecule. Pharmaceuticals, veterinary drugs, agricultural chemicals, industrial chemicals, research chemicals and many other beneficial compounds may be identified in accordance with embodiments of this invention.

  提供了用于识别调节生物分子的化合物的方法，可以抑制或刺激生物分子的活性。核酸，特别是RNA是这种调节的首选底物。这些方法特别强大，因为它们提供了新的技术组合，产生了通常是“小”有机化合物的高效调节剂，这些化合物高度调节RNA和其他生物分子的活性。根据发明的首选方面，可以同时测试大量的化合物，以确定它们是否可能与分子相互作用位点相互作用，并调节生物分子的活性。制药、兽药、农业化学品、工业化学品、研究化学品和许多其他有益的化合物可以根据本发明的实施方案进行识别。
• Modulation of molecular interaction sites on RNA and other biomolecules
  申请人：——

  公开号：US20030017483A1

  公开（公告）日：2003-01-23

  Methods for the identification of compounds which modulate, either inhibit or stimulate, biomolecules are provided. Nucleic acids, especially RNAs are preferred substrates for such modulation. The present methods are particularly powerful in that they provide novel combinations of techniques which give rise to compounds, usually “small” organic compounds, which are highly potent modulators of RNA and other biomolecular activity. In accordance with preferred aspects of the invention, very large numbers of compounds may be tested essentially simultaneously to determine whether they are likely to interact with a molecular interaction site and modulate the activity of the biomolecule. Pharmaceuticals, veterinary drugs, agricultural chemicals, industrial chemicals, research chemicals and many other beneficial compounds may be identified in accordance with embodiments of this invention.

  本研究提供了鉴定可抑制或刺激生物分子的化合物的方法。核酸，特别是 RNA 是这种调节的首选底物。本发明的方法特别强大，因为它们提供了新颖的技术组合，可以产生化合物，通常是 "小 "有机化合物，它们是 RNA 和其他生物分子活性的强效调节剂。根据本发明的优选方面，可以基本上同时测试大量化合物，以确定它们是否可能与分子相互作用位点相互作用并调节生物分子的活性。根据本发明的实施方案，可以鉴定出药品、兽药、农药、工业化学品、研究化学品和许多其他有益的化合物。
• GENERATION OF COMBINATORIAL LIBRARIES OF COMPOUNDS CORRESPONDING TO VIRTUAL LIBRARIES OF COMPOUNDS
  申请人：ISIS PHARMACEUTICALS, INC.

  公开号：EP1077993A1

  公开（公告）日：2001-02-28
• EP1077993A4
  申请人：——

  公开号：EP1077993A4

  公开（公告）日：2004-09-08
• MODULATION OF MOLECULAR INTERACTION SITES ON RNA AND OTHER BIOMOLECULES
  申请人：ISIS PHARMACEUTICALS, INC.

  公开号：EP1083980B1

  公开（公告）日：2007-03-21