6-(naphthalene-2-carbonylamino)-N-[(2S)-1-oxo-3-phenylpropan-2-yl]pyridine-3-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 6-(naphthalene-2-carbonylamino)-N-[(2S)-1-oxo-3-phenylpropan-2-yl]pyridine-3-carboxamide
• 化学式: C₂₆H₂₁N₃O₃
• 分子量: 423.5
• InChiKey: BBSHTZQZNAKBRB-QHCPKHFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  88.2
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Novel heterocyclically substituted amides, their preparation and use
  申请人：——

  公开号：US20040097508A1

  公开（公告）日：2004-05-20

  Amides of the general formula I 1 and their tautomeric and isomeric forms, possible enantiomeric and diastereomeric forms, as well as possible physiologically tolerable salts, in which the variables have the meanings stated in the description, their preparation and use as calpain inhibitors.

  通式I1的酰胺及其互变异构和同分异构形式，可能的对映异构体和顺反异构体形式，以及可能的生理耐受盐，其中变量的含义如描述中所述，它们的制备和用作钙蛋白酶抑制剂。
• HETEROZYKLISCHE SUBSTITUIERTE AMIDE, DEREN HERSTELLUNG UND ANWENDUNG
  申请人：Abbott GmbH & Co. KG

  公开号：EP1073638B1

  公开（公告）日：2008-07-23
• Endoluminal medical device for local delivery of cathepsin inhibitors, method of making and treating
  申请人：Biggs P. David

  公开号：US20070293937A1

  公开（公告）日：2007-12-20

  An endoluminal medical device comprises a drug release system that releases a cathepsin inhibitor at a predetermined location within a lumen of a patient. The endoluminal devices and methods of treatment of disease can treat illnesses such as aneurysms and aortic dissections.
• US6630493B1
  申请人：——

  公开号：US6630493B1

  公开（公告）日：2003-10-07
• [EN] ENDOLUMINAL MEDICAL DEVICE FOR LOCAL DELIVERY OF CATHEPSIN INHIBITORS AND METHOD OF MAKING SUCH A DEVICE<br/>[FR] APPAREIL MÉDICAL ENDOLUMINAL POUR LIVRAISON LOCALE D'INHIBITEURS DE LA CATHEPSINE ET MÉTHODE POUR CONSTRUIRE UN TEL APPAREIL
  申请人：MED INST INC

  公开号：WO2007081530A2

  公开（公告）日：2007-07-19

  [EN] An endoluminal medical device comprises a drug release system (125) that releases a cathepsin inhibitor at a predetermined location within a lumen of a patient. The endoluminal devices and methods of treatment of disease can treat illnesses such as aneurysms.
  [FR] L'invention concerne un appareil médical endoluminal comprenant un système de libération de médicament (125) qui libère un inhibiteur de la cathepsine en un lieu prédéterminé dans une lumière d'un patient. Les appareils endoluminaux et les méthodes de traitement de maladie peuvent traiter des maladies telles que des anévrismes.