1,1-dioxo-2-[4-[[(2R)-8-propan-2-yloxy-3,4-dihydro-2H-chromen-2-yl]methylamino]butyl]-1,2-benzothiazol-3-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 1,1-dioxo-2-[4-[[(2R)-8-propan-2-yloxy-3,4-dihydro-2H-chromen-2-yl]methylamino]butyl]-1,2-benzothiazol-3-one
• 化学式: C₂₄H₃₀N₂O₅S
• 分子量: 458.6
• InChiKey: GYSWPIMCQYACAP-LJQANCHMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  32
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  93.3
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Use of chromans
  申请人：——

  公开号：US20020177616A1

  公开（公告）日：2002-11-28

  The invention relates to the use of 2-[4-({[(2R)-8-isopropoxy-chroman-2-yl]-methyl}amino)butyl]-1,2-benzisothiazol-3(2H)-one 1,1-dioxide, its physiologically acceptable salts, hydrates and/or solvates, in particular its hydrochloride, for the production of a medicament for the prophylaxis and/or treatment of Parkinson's disease.

  该发明涉及使用2-［4-（［（2R）-8-异丙氧基-2-色基甲基］氨基）丁基］-1,2-苯并异噻唑-3（2H）-酮1,1-二氧化物及其生理上可接受的盐、水合物和/或溶剂化物，特别是其盐酸盐，用于制备用于预防和/或治疗帕金森病的药物。
• [EN] METHODS FOR TREATING SEXUAL DYSFUNCTION<br/>[FR] METHODES DE TRAITEMENT D'UN DYSFONCTIONNEMENT SEXUEL
  申请人：KESTREL PHARMACEUTICALS INC

  公开号：WO2005094827A1

  公开（公告）日：2005-10-13

  The present invention provides methods for treating hypoactive sexual desire disorder, the methods comprising the step of administering to a patient in need thereof a therapeutically effective amount of a compound that is a selective agonist at the 5-HT1A receptor. The above methods can be used to treat other sexual disorders in females, including (but not limited to) arousal disorder and orgasmic disorder. Optionally, the above methods can be used to treat male sexual dysfunction, including disorders of desire, arousal and orgasm.