3-(3,5-dibromo-4-(4-hydroxy-3-iso-propylphenylsulfonyl)phenyl)propionic acid

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: 3-(3,5-dibromo-4-(4-hydroxy-3-iso-propylphenylsulfonyl)phenyl)propionic acid
• 英文别名: 3-[3,5-Dibromo-4-(4-hydroxy-3-propan-2-ylphenyl)sulfonylphenyl]propanoic acid
• 化学式: C₁₈H₁₈Br₂O₅S
• 分子量: 506.212
• InChiKey: GYMREZBGMZNQRW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  100
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• METHOD OF TREATING HAIR LOSS USING SULFONYL THYROMIMETIC COMPOUNDS
  申请人：UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER

  公开号：EP1185232A1

  公开（公告）日：2002-03-13
• US5284971A
  申请人：——

  公开号：US5284971A

  公开（公告）日：1994-02-08
• US6646005B1
  申请人：——

  公开号：US6646005B1

  公开（公告）日：2003-11-11
• [EN] METHOD OF TREATING HAIR LOSS USING SULFONYL THYROMIMETIC COMPOUNDS<br/>[FR] METHODE DE TRAITEMENT DE LA PERTE DES CHEVEUX A L'AIDE DE COMPOSES DE SULFONYLE THYROMIMETIQUES
  申请人：UNIV TEXAS SOUTHWESTERN MED CT

  公开号：WO2000072810A1

  公开（公告）日：2000-12-07

  A method of treating hair loss comprising administering a composition comprising a cardiac-sparing compound characterized by structure (I) and pharmaceutically acceptable salts, hydrates, and biohydrolyzable amides, esters, and imides thereof, wherein: R1 is -(CH2)n(CHNR7R8)mC(O)R9; n is an integer from 1 to 3; m is an integer from 0 to 1; R3 and R5 are each, independently, selected from the group consisting of chlorine, bromine, iodine, and -CH3, R7 and R8 are each, independently, selected from the group consisting of hydrogen and C1-C4 alkyl; R9 is selected from the group consisting of hydroxy, C1-C4 alkoxy, and -NR7R8; R31 is selected from the group consisting of hydrogen, chlorine, bromine, iodine, C1-C4 alkyl, C4-C6 cycloalkyl, C1-C4 haloalkyl, C4-C6 halocycloalkyl, and -CH(R10)Ar; Ar is selected from the group consisting of 5-hydroxypyrid-2-yl, 6-hydroxypyrid-3-yl, 6-hydroxypyridazin-3-yl, 6-methoxypyridazin-3-yl N-oxide, and 6-hydroxypyridazin-3-yl N-oxide; R10 is selected from the group consisting of hydrogen and C1-C4 alkyl; and R41 is selected from the group consisting of hydroxy and C1-C4 alkoxy.