(R)-N-Cyanomethyl-3-[2-(1,1-difluoro-methoxy)-phenylmethanesulfonyl]-2-(naphthalene-2-sulfonylamino)-propionamide | 330475-37-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (R)-N-Cyanomethyl-3-[2-(1,1-difluoro-methoxy)-phenylmethanesulfonyl]-2-(naphthalene-2-sulfonylamino)-propionamide
• 英文别名: (2R)-N-(cyanomethyl)-3-[[2-(difluoromethoxy)phenyl]methylsulfonyl]-2-(naphthalen-2-ylsulfonylamino)propanamide
• CAS: 330475-37-1
• 化学式: C₂₃H₂₁F₂N₃O₆S₂
• 分子量: 537.565
• InChiKey: FLLRDSGLTTVRHJ-FQEVSTJZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  36
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  159
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• Novel compounds and compositions as cathepsin S inhititors
  申请人：AXYS PHARMACEUTICALS, INC.

  公开号：US20040014796A1

  公开（公告）日：2004-01-22

  The present invention relates to novel selective cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.

  本发明涉及新型选择性卡痕蛋白S抑制剂，其药学上可接受的盐和N-氧化物，它们作为治疗剂的用途以及它们的制备方法。
• COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS
  申请人：AXYS PHARMACEUTICALS, INC.

  公开号：EP1212302A1

  公开（公告）日：2002-06-12
• USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC
  申请人：AXYS PHARMACEUTICALS, INC.

  公开号：EP1694357A1

  公开（公告）日：2006-08-30
• US6492362B1
  申请人：——

  公开号：US6492362B1

  公开（公告）日：2002-12-10
• [EN] COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS<br/>[FR] COMPOSES ET COMPOSITIONS PHARMACEUTIQUES UTILISES COMME INHIBITEURS DE LA CATHEPSINE S
  申请人：AXYS PHARM INC

  公开号：WO2001019796A1

  公开（公告）日：2001-03-22

  The present invention relates to novel selective cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.