3-(Hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 3-(Hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol
• 化学式: C₁₀H₁₃NO₃
• 分子量: 195.21
• InChiKey: CEGHCZLLQKXQCY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  72.7
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• 3-Substituted 6,7-dihydroxytetrahydroisoquinoline derivatives for use as antibacterial agents
  申请人：——

  公开号：US20040266817A1

  公开（公告）日：2004-12-30

  The invention relates to novel tetrahydroisoquinoline derivatives of general formula I and theirs use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and their use as anti-infectives, wherein R 1 , R 2 and R 3 are as defined in claim 1.

  本发明涉及一种新型四氢异喹啉衍生物，其通式为I，并且它们作为制备药物组成物的活性成分的用途。本发明还涉及相关方面，包括制备化合物的过程，含有其中一种或多种化合物的制药组合物以及它们作为抗感染药物的用途，其中R1、R2和R3如权利要求1所定义。
• 3-SUBSTITUTED 6,7-DIHYDROXYTETRAHYDROISOQUINOLINE DERIVATIVES FOR USE AS ANTIBACTERIAL AGENTS
  申请人：Arpida AG

  公开号：EP1427417B1

  公开（公告）日：2008-02-20
• US7371762B2
  申请人：——

  公开号：US7371762B2

  公开（公告）日：2008-05-13
• [EN] 3-SUBSTITUTED 6,7-DIHYDROXYTETRAHYDROISOQUINOLINE DERIVATIVES FOR USE AS ANTIBACTERIAL AGENTS<br/>[FR] DERIVES DE 6,7-DIHYDROXYTETRAHYDROISOQUINOLINE 3-SUBSTITUTES UTILISES COMME AGENTS ANTIBACTERIENS
  申请人：ARPIDA AG

  公开号：WO2003018017A1

  公开（公告）日：2003-03-06

  The invention relates to novel tetrahydroisoquinoline derivatives of general formula I and theirs use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and their use as anti-infectives, wherein R?1, R2 and R3¿ are as defined in claim 1.