3-Hydroxy-2,2-dimethyl-4-(2-oxopiperidin-1-yl)-3,4-dihydrochromene-6-sulfonamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 3-Hydroxy-2,2-dimethyl-4-(2-oxopiperidin-1-yl)-3,4-dihydrochromene-6-sulfonamide
• 化学式: C₁₆H₂₂N₂O₅S
• 分子量: 354.4
• InChiKey: OTBNEOLRNMGPQP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  118
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• [EN] BENZOPYRANS HAVING POTASSIUM CHANNEL OPENING ACTIVITY<br/>[FR] BENZOPYRANNES POSSEDANT UNE ACTIVITE D'OUVERTURE DES CANAUX A POTASSIUM
  申请人：NOVARTIS AG

  公开号：WO2000021957A1

  公开（公告）日：2000-04-20

  A compound of formula (I) where the indicated OH group in the 3- position is in the trans position with respect to R?3, and R1 and R2¿ are independently hydrogen or C¿1? to C5 alkyl, R?3¿ is a group of the formula: -N(R6)-COR7 where R6 is hydrogen or C¿1? to C5 alkyl and R?7¿ is a C¿6? to C10 monovalent aromatic group or a monovalent heteroaromatic group having a 5- or 6-membered heteroaromatic ring, or R?6 and R7¿ together are 1,3-butadienylene or denote a group of formula -(CH¿2?)m- or formula (II) in which m is an integer of from 3 to 5 and n is 1 or 2, and R?4 and R5¿ are, independently, C¿1? to C5 alkyl; or a N-oxide thereof; or a physiologically-hydrolysable and -acceptable ester of a compound of formula (I) or N-oxide thereof; or a physiologically acceptable acid addition or quaternary ammonium salt of a compound of formula (I), or of an ester or N-oxide thereof.