NS 1219

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: NS 1219
• 英文别名: (R)-2-[5-(4-dimethylsulfamoyl-phenyl)-8-methyl-2-oxo-1,2,6,7,8,9-hexahydro-pyrrolo [3,2-h]isoquinolin-3-ylideneaminooxy]-4-hydroxy-butyric acid；(2R)-2-[[5-[4-(dimethylsulfamoyl)phenyl]-8-methyl-2-oxo-1,6,7,9-tetrahydropyrrolo[3,2-h]isoquinolin-3-ylidene]amino]oxy-4-hydroxybutanoic acid
• 化学式: C₂₄H₂₈N₄O₇S
• 分子量: 516.575
• InChiKey: CFJRSKULEDUDKL-HXUWFJFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  36
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  157
• 氢给体数：
  3
• 氢受体数：
  10

文献信息

• Method of preparing enantiomers of indole-2,3-dione-3-oxime derivatives
  申请人：Gouliaev H Alex

  公开号：US20060178391A1

  公开（公告）日：2006-08-10

  The present invention is directed to a method of preparing enantiomers of indole-2,3-dione-3-oxime derivatives.

  本发明涉及一种制备吲哚-2,3-二酮-3-肟衍生物对映体的方法。
• PHARMACEUTICAL COMPOSITIONS COMPRISING COMBINATIONS OF AN AMPA/KAINATE ANTAGONISTIC COMPOUND AND AN INHIBITOR OF A MULTIDRUG RESISTANCE PROTEIN
  申请人：Weikop Pia

  公开号：US20100041691A1

  公开（公告）日：2010-02-18

  This invention relates to pharmaceutical compositions comprising a combination of an AMPA/kainate antagonistic compound and an inhibitor of a multidrug resistance protein and its use for combating epileptic disorders.