Guanosintetraphosphat | 3369-85-5

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 英文名称: Guanosintetraphosphat
• 英文别名: O^5'-(pentahydroxy-[1]tetraphosphoryl)-guanosine；guanosine 5'-tetraphosphate；Guanosine 5'-tetraphosphate；[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [hydroxy(phosphonooxy)phosphoryl] hydrogen phosphate
• CAS: 3369-85-5
• 化学式: C₁₀H₁₇N₅O₁₇P₄
• 分子量: 603.163
• InChiKey: KDFXXNGTULMGMF-UUOKFMHZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -7.6
• 重原子数：
  36
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  341
• 氢给体数：
  9
• 氢受体数：
  18

反应信息

• 作为产物：
  描述：

  鸟苷酸 在 Meiothermus ruber polyphosphate kinase L₁₃₆A 、 magnesium chloride 作用下， 以 aq. buffer 为溶剂， 生成 鸟苷-5’-二磷酸 、 Guanosine 5'-triphosphate 、 Guanosintetraphosphat
  参考文献：
  名称：

  10.1002/cctc.202400181

  摘要：

  AbstractPolyphosphate kinases (PPKs) are valuable biocatalysts for ATP cofactor regeneration as well as for the phosphorylation of non‐canonical nucleotides. The versatility of PPKs in the latter application is defined by their substrate scope. In this study, we investigate the substrate spectrum of the PPK2‐III enzyme from Meiothermus ruber (MrPPK) for the conversion of canonical and non‐canonical (deoxy)‐ribonucleotides. The enzyme shows high substrate promiscuity for purine and to minor degree pyrimidine substrates, with an overall preference for the native substrate AMP. With structure guided rational amino acid exchanges in the active site, we produced an MrPPK variant with improved activity for a broad variety of purine nucleotides. While the preference for AMP is lost, conversion of nucleotides without a 6‐amino function at the purine moiety is increased. This MrPPK variant is a versatile biocatalyst for the synthesis of non‐canonical nucleotides and could also be useful as a GTP cofactor regeneration system.

  DOI：

  10.1002/cctc.202400181

文献信息

• COMPOUNDS FOR TREATING BACTERIAL INFECTIONS
  申请人：Glaser Gad

  公开号：US20110086813A1

  公开（公告）日：2011-04-14

  The present invention relates to a novel class of guanine nucleotide analogs which inhibit RelA and Relseq synthetic activity and which possess anti-bacterial activity. The present invention also relates to pharmaceutical compositions that include such compounds, and to methods of use of such compounds or compositions for combating bacteria and treating bacterial infections.

  本发明涉及一类新型鸟嘌呤核苷酸类似物，其抑制RelA和Relseq的合成活性，并具有抗细菌活性。本发明还涉及包括这些化合物的药物组合物，以及利用这些化合物或组合物来对抗细菌和治疗细菌感染的方法。
• [EN] N-SUBSTITUTED-1H-1,2,4-TRIAZOLE-3-CARBOXAMIDES, ANALOGUES THEREOF, AND METHODS OF TREATMENT USING SAME<br/>[FR] 1H-1,2,4-TRIAZOLE-3-CARBOXAMIDES N-SUBSTITUÉS, ANALOGUES DE CEUX-CI, ET MÉTHODES DE TRAITEMENT FAISANT APPEL À CEUX-CI
  申请人：UNIV COLORADO REGENTS

  公开号：WO2020041556A1

  公开（公告）日：2020-02-27

  The present invention relates to the discovery of novel N-(substituted)-1H-1,2,4-triazole-3-carboxamide compounds capable of inhibiting DksA activity in a bacteria cell. In certain embodiments, the compounds are capable of killing or weakening bacteria. In another aspect, the invention relates to methods of treating bacterial infection in a subject in need thereof, the method comprising administering to the subject a compound of the invention.

  本发明涉及发现的新型N-(取代)-1H-1,2,4-三唑-3-羧酰胺化合物，能够抑制细菌细胞中的DksA活性。在某些实施方式中，这些化合物能够杀灭或削弱细菌。另一方面，本发明涉及治疗患有细菌感染的受试者的方法，该方法包括向受试者施用本发明的化合物。
• Synthesis and compositions of 2'-terminator nucleotides
  申请人：Bodepudi Veeraiah

  公开号：US20050037991A1

  公开（公告）日：2005-02-17

  The invention provides compositions the comprise nucleotides and/or nucleosides having blocking groups at 2′-positions of sugar moieties. Methods of synthesizing these nucleic acids are also provided.

  该发明提供了含有在糖基的2′-位置具有阻断基团的核苷酸和/或核苷的组合物。同时还提供了合成这些核酸的方法。
• Highly homogeneous molecular markers for electrophoresis
  申请人：Invitrogen Corporation

  公开号：US20040014082A1

  公开（公告）日：2004-01-22

  The invention relates to marker molecules for identifying physical properties of molecular species separated by the use of electrophoretic systems. The invention further relates to methods for preparing and using marker molecules.

  这项发明涉及用于识别电泳系统分离的分子物种的物理性质的标记分子。该发明还涉及制备和使用标记分子的方法。
• [EN] RELA INHIBITORS FOR BIOFILM DISRUPTION<br/>[FR] INHIBITEURS DE RELA POUR LA RUPTURE D'UN BIOFILM
  申请人：UNIV DREXEL

  公开号：WO2018213185A1

  公开（公告）日：2018-11-22

  Pharmaceutical compositions comprising a RelA enzyme inhibitor and a bactericidal antibiotic, wherein said RelA enzyme inhibitor binds to the RelA enzyme in bacteria to reduce biofilm formation and to degrade biofilms that have been formed. The pharmaceutical compositions can be used to treat bacterial biofilm diseases.

  药物组合物包括RelA酶抑制剂和杀菌性抗生素，其中所述的RelA酶抑制剂与细菌中的RelA酶结合，以减少生物膜的形成并分解已形成的生物膜。该药物组合物可用于治疗细菌生物膜疾病。