(3S,4R)-(+)-N-[3-Hydroxy-2,2-dimethyl-6-(4,4,4-trifluoro-butoxy)-chroman-4-yl]-N-methyl-methanesulfonamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: (3S,4R)-(+)-N-[3-Hydroxy-2,2-dimethyl-6-(4,4,4-trifluoro-butoxy)-chroman-4-yl]-N-methyl-methanesulfonamide
• 英文别名: N-[(3S,4R)-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-3,4-dihydrochromen-4-yl]-N-methylmethanesulfonamide
• 化学式: C₁₇H₂₄F₃NO₅S
• 分子量: 411.4
• InChiKey: SRZRLJWUQFIZRH-CABCVRRESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  84.4
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• Use of inhibitors of the KQT1 channel and methods of controlling and treating diseases caused by helminths and ectoparasites
  申请人：Aventis Pharma Deutschland GMBH

  公开号：US20020055537A1

  公开（公告）日：2002-05-09

  Use of inhibitors of the KQT1 channel for preparing a medicament for treating diseases caused by helminths and ectoparasites Inhibitors of the KQT1 channel are a novel way of destroying helminths and ectoparasites. For this reason, blockers of the cellular KQT1 channel, which is present in helminths and ectoparasites, are used for preparing a medicament for the treatment of vertebrates and humans infested by helminths or ectoparasites. These KQT1 blockers are used as medicaments on their own or in combination with other medicaments and therapeutic measures. Inhibitors of the KQT1 channel are likewise a novel mechanism of action for phytoparasites such as insects, arachnids, molluscs and nematodes, and consequently, they are used for preparing a crop protection composition.

  使用 KQT1 通道抑制剂制备治疗蠕虫和体外寄生虫引起的疾病的药物 KQT1 通道抑制剂是消灭蠕虫和体外寄生虫的一种新方法。因此，蠕虫和体外寄生虫体内的细胞 KQT1 通道阻断剂可用于制备治疗脊椎动物和人类蠕虫或体外寄生虫疾病的药物。这些 KQT1 阻断剂可单独用作药物，也可与其他药物和治疗措施结合使用。 KQT1 通道抑制剂同样也是一种针对植物寄生虫（如昆虫、蛛形纲动物、软体动物和线虫）的新型作用机制，因此可用于制备作物保护组合物。
• VERWENDUNG VON INHIBITOREN DES KQT1-KANALS ZUR HERSTELLUNG EINES MEDIKAMENTS ZUR BEHANDLUNG VON KRANKHEITEN, DIE DURCH HELMINTHEN UND EKTOPARASITEN HERVORGERUFEN WERDEN
  申请人：Sanofi-Aventis Deutschland GmbH

  公开号：EP1140042B1

  公开（公告）日：2008-03-26
• US6008245A
  申请人：——

  公开号：US6008245A

  公开（公告）日：1999-12-28
• US6335363B1
  申请人：——

  公开号：US6335363B1

  公开（公告）日：2002-01-01