tert-butyl N-[2-[4-(6-methoxynaphthalen-2-yl)-5-pyridin-4-yl-1H-imidazol-2-yl]-2-methylpropyl]carbamate

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: tert-butyl N-[2-[4-(6-methoxynaphthalen-2-yl)-5-pyridin-4-yl-1H-imidazol-2-yl]-2-methylpropyl]carbamate
• 化学式: C₂₈H₃₂N₄O₃
• 分子量: 472.6
• InChiKey: GDFNXHBZSMGJEF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  35
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  89.1
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• NOVEL COMPOUNDS
  申请人：Adams L. Jerry

  公开号：US20070010534A1

  公开（公告）日：2007-01-11

  The present invention is directed to novel compounds of Formula (I) for use in the treatment of diseases, in a mammal, in which inappropriate, excessive or undesirable angiogenesis has occurred and/or where excessive Tie2 receptor activity has occurred.

  本发明涉及一种新型化合物（I）的使用，用于治疗哺乳动物中发生不当、过度或不良血管生成以及/或过度Tie2受体活性的疾病。
• EP1233769A4
  申请人：——

  公开号：EP1233769A4

  公开（公告）日：2004-12-29
• Imidazole derivatives
  申请人：SMITHKLINE BEECHAM PLC

  公开号：EP1233769B1

  公开（公告）日：2007-12-26
• US7189745B1
  申请人：——

  公开号：US7189745B1

  公开（公告）日：2007-03-13
• [EN] NOVEL COMPOUNDS<br/>[FR] NOUVEAUX COMPOSES
  申请人：SMITHKLINE BEECHAM PLC

  公开号：WO2001037835A1

  公开（公告）日：2001-05-31

  The present invention is directed to novel compounds of Formula (I) for use in the treatment of diseases, in a mammal, in which inappropriate, excessive or undesirable angiogenesis has occurred and/or where excessive Tie2 receptor activity has occurred.