5-fluoro-1H-pyrimidine-2,4-dione;5-[[4-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromen-2-yl)methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 5-fluoro-1H-pyrimidine-2,4-dione;5-[[4-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromen-2-yl)methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
• 化学式: C28H30FN3O7S
• 分子量: 571.6
• InChiKey: NTUXRYYTOMYUBK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.58
• 重原子数：
  40
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  168
• 氢给体数：
  4
• 氢受体数：
  9

文献信息

• [EN] A METHOD FOR PREDICTING A SUBJECT'S RESPONSE TO SLC MODULATOR THERAPY<br/>[FR] PROCÉDÉ POUR PRÉDIRE LA RÉPONSE D'UN PATIENT À UN TRAITEMENT PAR MODULATEURS DE SLC
  申请人：UNIV COLUMBIA

  公开号：WO2019046303A1

  公开（公告）日：2019-03-07

  The present invention provides, inter alia, methods for treating or ameliorating the effects of a disorder, such as schizophrenia or bipolar disorder, by increasing or decreasing proline levels. Further provided are methods of predicting and monitoring the clinical response in a patient, and diagnostic systems for identifying a patient likely to benefit from proline modulation.