2-(Naphthalen-1-ylmethyl)-5-sulfanylpentanoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-(Naphthalen-1-ylmethyl)-5-sulfanylpentanoic acid
• 化学式: C₁₆H₁₈O₂S
• 分子量: 274.4
• InChiKey: HTICMHJMTDPVRK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  38.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Thiol-based NAALADase inhibitors
  申请人：Tsukamoto Takashi

  公开号：US20050085503A1

  公开（公告）日：2005-04-21

  This invention relates to new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF-β activity, inhibiting angiogenesis, and treating glutamate abnormalities, diabetic neuropathy, pain, compulsive disorders, prostate diseases, cancers and glaucoma.

  本发明涉及新化合物、制药组合物和诊断试剂盒，包括这些化合物，并使用这些化合物抑制NAALADase酶活性、检测NAALADase水平发生变化的疾病、影响神经元活动、影响TGF-β活性、抑制血管生成以及治疗谷氨酸异常、糖尿病神经病变、疼痛、强迫性障碍、前列腺疾病、癌症和青光眼。
• THIOL-BASED NAALADASE INHIBITORS
  申请人：GUILFORD PHARMACEUTICALS INC.

  公开号：EP1353903A2

  公开（公告）日：2003-10-22
• US6992215B2
  申请人：——

  公开号：US6992215B2

  公开（公告）日：2006-01-31
• [EN] THIOL-BASED NAALADASE INHIBITORS<br/>[FR] INHIBITEURS DE NAALADASE A BASE DE THIOL
  申请人：GUILFORD PHARM INC

  公开号：WO2002057222A2

  公开（公告）日：2002-07-25

  This invention relates to thiol compounds of the formulae I, II or III (in which the variables are as defined in the claims), pharmaceutical compositions and diagnostic kits comprising such compounds and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF-β activity, inhibiting angiogenesis, and treating glutamate abnormalities, diabetic neuropathy, pain, compulsive disorders, prostate diseases, cancers and glaucoma.