(E)-4-[2-(5-methoxymethyl-5-methyl-2,3,4,5-tetrahydrobenzo[b]oxepin-8-yl)-vinyl]-benzoic acid | 327627-83-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (E)-4-[2-(5-methoxymethyl-5-methyl-2,3,4,5-tetrahydrobenzo[b]oxepin-8-yl)-vinyl]-benzoic acid
• 英文别名: 4-[(E)-2-[5-(methoxymethyl)-5-methyl-3,4-dihydro-2H-1-benzoxepin-8-yl]ethenyl]benzoic acid
• CAS: 327627-83-8
• 化学式: C₂₂H₂₄O₄
• 分子量: 352.43
• InChiKey: AQRRFBSTUODWOG-SNAWJCMRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Methods for treating multiple osteochondroma (MO)
  申请人：Clementia Pharmaceuticals Inc.

  公开号：US10980778B2

  公开（公告）日：2021-04-20

  The invention features methods for inhibiting the formation, reducing the size, and slowing the growth of an osteochondroma in a subject with multiple osteochondroma (MO) by administering to the subject palovarotene (also known as R667), or a pharmaceutically acceptable salt thereof. The methods described herein can also ameliorate complications associated with osteochondroma formation and growth in a subject with MO.

  本发明的特点是通过向多发性骨软骨瘤（MO）患者施用帕罗伐汀（又称 R667）或其药学上可接受的盐，抑制骨软骨瘤的形成、减小其大小并减缓其生长。本文所述的方法还可以改善与MO患者骨软骨瘤形成和生长相关的并发症。
• BENZOPYRANS AND BENZOTHIOPYRANS AS RAR SELECTIVE RETINOID AGONISTS
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP1212316A2

  公开（公告）日：2002-06-12
• SMALL MOLECULE CELLULAR REPROGRAMMING TO GENERATE NEURONAL CELLS
  申请人：The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone

  公开号：EP3039126A2

  公开（公告）日：2016-07-06
• CHEMICAL REPROGRAMMING TO GENERATE NEURONAL CELLS
  申请人：The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone

  公开号：EP3331988A1

  公开（公告）日：2018-06-13
• EPIDERMAL NEURAL CREST STEM CELLS AS A SOURCE OF SCHWANN CELLS
  申请人：Sieber-Blum Maya

  公开号：US20180140637A1

  公开（公告）日：2018-05-24

  The application describes compositions, kits, and methods for generating Schwann cells from epidermal neural crest stem cells (EPI-NCSC). Such EPI-NCSC can be obtained from the bulge of hair follicles.