2-[[4-(1-benzothiophen-3-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-3,7-dihydro-2H-[1,4]dioxino[2,3-e]indole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并二恶烷
• 英文名称: 2-[[4-(1-benzothiophen-3-yl)-3,6-dihydro-2H-pyridin-1-yl]methyl]-3,7-dihydro-2H-[1,4]dioxino[2,3-e]indole
• 化学式: C₂₄H₂₂N₂O₂S
• 分子量: 402.5
• InChiKey: KGWGWNSDSOKQFO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  65.7
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] ANTIDEPRESSANT PIPERIDINE DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXANS<br/>[FR] DERIVES PIPERIDINE D'HETEROCYCLE DE BENZODIOXANS FUSIONNES EN TANT QU'ANTIDEPRESSEURS
  申请人：WYETH CORP

  公开号：WO2004024733A1

  公开（公告）日：2004-03-25

  Compounds of the Formula: are useful for the treatment of depression (including but not limited to major depressive disorder, chi ldhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as premenstrual syndrome), attention deficit disorder (wit h and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.

  该公式化合物用于治疗抑郁症（包括但不限于重性抑郁障碍、儿童抑郁和忧郁症）、焦虑、恐慌障碍、创伤后应激障碍、经前期失调性障碍（也称为经前综合征）、注意力缺陷障碍（有和无多动症）、强迫症、社交焦虑障碍、广泛性焦虑障碍、肥胖症、厌食症和暴食症、血管运动性潮红、可卡因和酒精成瘾、性功能障碍及相关疾病。
• Antidepressant piperidine derivatives of heterocycle-fused benzodioxans
  申请人：——

  公开号：US20040147523A1

  公开（公告）日：2004-07-29

  Compounds of the Formula: 1 are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as premenstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.

  式子为1的化合物对于治疗抑郁症（包括但不限于重度抑郁症、儿童抑郁症和慢性抑郁症）、焦虑症、恐慌症、创伤后应激障碍、经前期不良情绪障碍（也称经前综合征）、注意力缺陷障碍（有或无多动症）、强迫症、社交焦虑症、广泛性焦虑症、肥胖症、进食障碍（如厌食症和贪食症）、血管活性药物潮红、可卡因和酒精成瘾、性功能障碍及相关疾病具有治疗作用。
• Antidepressant piperidine derivatives of heterocyclefused benzodioxans
  申请人：Webb Byron Michael

  公开号：US20050228009A1

  公开（公告）日：2005-10-13

  Compounds of the Formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.

  公式为的化合物可用于治疗抑郁症（包括但不限于重度抑郁症、儿童抑郁症和慢性抑郁症）、焦虑、惊恐障碍、创伤后应激障碍、经前期不良情绪障碍（也称经前综合症）、注意力缺陷障碍（伴有或不伴有多动症）、强迫症、社交焦虑症、广泛性焦虑症、肥胖症、进食障碍如厌食症和贪食症、潮红、可卡因和酒精成瘾、性功能障碍及相关疾病。
• Antidepressant Piperidine Derivatives of Heterocycle-Fused Benzodioxans
  申请人：Webb Michael Byron

  公开号：US20090042895A1

  公开（公告）日：2009-02-12

  Compounds of the Formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.

  公式为：的化合物可用于治疗抑郁症（包括但不限于重度抑郁症、儿童抑郁症和心境恶劣）、焦虑症、恐慌症、创伤后应激障碍、经前期症候群（也称经前综合征）、注意力缺陷多动障碍（有和无过动症）、强迫症、社交焦虑症、广泛性焦虑症、肥胖症、饮食失调如厌食症和贪食症、潮红、可卡因和酒精成瘾、性功能障碍及相关疾病。
• ANTIDEPRESSANT PIPERIDINE DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXANS
  申请人：Wyeth, A Corporation of the State of Delaware

  公开号：EP1537120A1

  公开（公告）日：2005-06-08