N-methyl-8-naphthalen-2-yloxyoctan-1-amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-methyl-8-naphthalen-2-yloxyoctan-1-amine
• 化学式: C₁₉H₂₇NO
• 分子量: 285.4
• InChiKey: CWVGWEDXMGBKBJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  21
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] AMINE COMPOUNDS<br/>[FR] COMPOSES D'AMINE
  申请人：BTG INT LTD

  公开号：WO2002024619A1

  公开（公告）日：2002-03-28

  Ar is a bicyclic or tricyclic aromatic group including at least one benzene ring, the oxygen group of the side chain being attached to the benzene ring of Ar; A is a straight or branched alkylene group of 6 to 16 carbon atoms which may be interrupted by -O-, -S-, -SO-, -SO2-, -NR4-, -CH(OH)- or -CO-, wherein R4 is hydrogen or a straight or branched alkyl group of 1 to 4 carbon atoms; and R?1 and R2¿ are each independently hydrogen or a straight or branched alkyl or alkenyl group of 1 to 4 carbon atoms, optionally substituted by phenyl or a cycloalkyl group of 3 to 7 carbon atoms; are useful for the treatment of fungal infection.