7-(naphthalen-2-ylmethoxy)-8-propyl-3,4-dihydro-2H-chromene-2-carboxylic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 7-(naphthalen-2-ylmethoxy)-8-propyl-3,4-dihydro-2H-chromene-2-carboxylic acid
• 化学式: C₂₄H₂₄O₄
• 分子量: 376.4
• InChiKey: OEEKXJLBWCJRND-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• USE OF NON-PEPTIDYL COMPOUNDS FOR THE TREATMENT OF INSULIN RELATED AILMENTS
  申请人：CURTIN UNIVERSITY OF TECHNOLOGY

  公开号：EP1115422A1

  公开（公告）日：2001-07-18
• EP1115422A4
  申请人：——

  公开号：EP1115422A4

  公开（公告）日：2003-01-29
• US6933272B1
  申请人：——

  公开号：US6933272B1

  公开（公告）日：2005-08-23
• [EN] USE OF NON-PEPTIDYL COMPOUNDS FOR THE TREATMENT OF INSULIN RELATED AILMENTS<br/>[FR] UTILISATION DE COMPOSES NON-PEPTIDYLIQUES POUR LE TRAITEMENT D'AFFECTIONS LIEES A L'INSULINE
  申请人：UNIV CURTIN TECH

  公开号：WO2000016798A1

  公开（公告）日：2000-03-30

  The present invention relates to the use of at least a non-peptidyl compound as a biological modulator of insulin activity or insulin-related activity, which compound possesses ionic and hydrophobic chemical moieties spatially located so as to mimic at least an ionic and hydrophobic amino acid residue of insulin, which amino acids are associated with the binding of insulin to its receptor.