16-Methyl-3-oxa-23-aza-9-azoniaheptacyclo[17.7.1.15,9.02,17.04,15.023,27.013,28]octacosa-1(27),2(17),4,9(28),13,15,18-heptaene

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 16-Methyl-3-oxa-23-aza-9-azoniaheptacyclo[17.7.1.15,9.02,17.04,15.023,27.013,28]octacosa-1(27),2(17),4,9(28),13,15,18-heptaene
• 化学式: C26H29N2O+
• 分子量: 385.5
• InChiKey: KIGCHKXNAYGNSP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  29
• 可旋转键数：
  0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  15.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• POLYMER PARTICLES OR NANO-VECTORS AND USE THEREOF AS A DRUG AND/OR DIAGNOSTIC AGENT
  申请人：Bertrand Philippe

  公开号：US20140219925A1

  公开（公告）日：2014-08-07

  Novel polymer nanovectors or particles and use thereof as medication and/or diagnostic agents.

  新型聚合物纳米载体或颗粒及其作为药物和/或诊断试剂的用途。
• NOVEL TEMPERATURE-SENSITIVE FLUORESCENT COMPOUND AND APPLICATION THEREOF
  申请人：SHANGHAI INSTITUTES FOR BIOLOGICAL SCIENCES, CHINESE ACADEMY OF SCIENCES

  公开号：US20160376247A1

  公开（公告）日：2016-12-29

  Provided is a compound represented by formula I, wherein R 9 is a C1-C22 hydrocarbyl group, or a C2-C3 ester-substituted C1-C3 alkyl group, R 5 , R 6 , R 7 , and R 8 are alkyl groups or H, and R 1 , R 2 , R 3 , and R 4 are H or a lower hydrocarbyl group. Or, R 9 is a C2-C22 hydrocarbyl group, or a C2-C3 ester-substituted C1-C3 alkyl group, and R 5 is connected to R 1 , R 6 is connected to R 2 , R 7 is connected to R 3 , R 8 is connected to R 4 to form six-membered rings. The present compound is temperature-sensitive and can enter into cells. An intracellular temperature distribution image having high spatial and temporal resolution can thus be obtained. The present compound can also perform distribution calibration on a temperature-sensitive fluorescent compound. Also provided is a method for measuring temperature distribution within a living cell, and a corresponding detection kit. The method satisfies the requirements of small size measurement and rapid measurement, thereby achieving high resolution in terms of space and time.

  提供的化合物由式I表示，其中R9是一个C1-C22烃基团，或者是一个C2-C3酯基取代的C1-C3烷基基团，R5、R6、R7和R8是烷基基团或氢，而R1、R2、R3和R4是氢或较低烃基基团。或者，R9是一个C2-C22烃基团，或者是一个C2-C3酯基取代的C1-C3烷基基团，而R5连接到R1，R6连接到R2，R7连接到R3，R8连接到R4形成六元环。这种化合物对温度敏感，可以进入细胞。因此，可以获得具有高空间和时间分辨率的细胞内温度分布图像。这种化合物还可以对温度敏感的荧光化合物进行分布校准。还提供了一种测量活细胞内温度分布的方法和相应的检测工具包。该方法满足了小尺寸测量和快速测量的要求，从而在空间和时间上实现高分辨率。
• Fluorescent red emitting functionalizable pH probes
  申请人：Paris Sciences et Lettres - Quartier Latin

  公开号：EP2889299A1

  公开（公告）日：2015-07-01

  The present invention relates to pH probes of formula I: wherein: W represents O, NH, N(alkyl), Si(alkyl)2, CH2, CH(alkyl), C(alkyl)2; preferably W represents O; X1 and X1' represent both H, both Me or both -CH2-SO3H; X2 and X2' represent both H or both Me; X3 and X3' represent both H or both Me; X4 and X4' represent both H or both Me; X5 and X5' represent both H or both Me; X6 and X6' represent both H or both Me; Z1, Z2 and Z3, represent each independently H, electron withdrawing group or electron donating group, L represents a single bound or a linker, Y represents a reactive group, or a bioactive group, and a process for manufacturing said compounds. The invention further relates to the use of the compounds of the invention as pH probes.

  本发明涉及公式I的pH探针：其中：W代表O，NH，N（烷基），Si（烷基）2，CH2，CH（烷基），C（烷基）2;优选W代表O;X1和X1'代表两个H，两个Me或两个-CH2-SO3H;X2和X2'代表两个H或两个Me;X3和X3'代表两个H或两个Me;X4和X4'代表两个H或两个Me;X5和X5'代表两个H或两个Me;X6和X6'代表两个H或两个Me;Z1，Z2和Z3分别独立地表示H，电子提取基团或电子捐赠基团，L表示单一键或连接剂，Y表示反应性基团或生物活性基团，并且本发明进一步涉及制造所述化合物的过程。本发明还涉及将本发明化合物用作pH探针的用途。
• FLUORESCENT RED EMITTING FUNCTIONALIZABLE CALCIUM INDICATORS
  申请人：PARIS SCIENCES ET LETTRES - QUARTIER LATIN

  公开号：US20160376441A1

  公开（公告）日：2016-12-29

  Compounds of formula I and a process for manufacturing the compounds. A method of using the compounds for the detection of calcium ions and a method of detecting intracellular calcium are also described.
• STIMULATED RAMAN COUPLED FLUORESCENCE SPECTROSCOPY AND MICROSCOPY SYSTEM AND METHOD
  申请人：MIN WEI

  公开号：US20210404958A1

  公开（公告）日：2021-12-30

  Exemplary computer-accessible medium, systems, and methods are described herein which can provide an excited fluorescence radiation. In accordance with certain exemplary embodiments of the present disclosure, an excited fluorescence radiation can be provided using a beam of a probe so as to excite a molecule to an excited state for a fluorescence emission to effectuate the excited fluorescence radiation. The molecule can be detected based on the fluorescence emission. For example, the beam of the probe can be either the near-infrared spectrum or the visible light spectrum.