1-formyl-N-[2-[4-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)piperidin-1-yl]ethyl]piperidine-4-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 二苯并环庚烯
• 英文名称: 1-formyl-N-[2-[4-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)piperidin-1-yl]ethyl]piperidine-4-carboxamide
• 化学式: C₂₉H₃₅N₃O₂
• 分子量: 457.6
• InChiKey: PZCCLNJJMYKXQZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  34
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  52.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• PIPERIDINE DERIVATIVES AND ANTI-PLATELET AGENTS CONTAINING THE SAME
  申请人：——

  公开号：US20020019533A1

  公开（公告）日：2002-02-14

  The present invention relates to a novel serotonin antagonist and an anti-platelet agent, more particularly, a serotonin antagonist and an anti-platelet agent which potently and specifically inhibit the serotonin 2 receptor with low adverse side effect.

  本发明涉及一种新型的血清素拮抗剂和抗血小板药物，更具体地说，是一种血清素拮抗剂和抗血小板药物，其能够强而有力地、特异性地抑制血清素2受体，且副作用低。
• Piperidine derivatives and anti-platelet agents containing the same
  申请人：AJINOMOTO CO., INC.

  公开号：US20020147195A1

  公开（公告）日：2002-10-10

  The present invention relates to a novel serotonin antagonist and an anti-platelet agent, more particularly, a serotonin antagonist and an anti-platelet agent which potently and specifically inhibit the serotonin 2 receptor with low adverse side effect.

  本发明涉及一种新型的5-羟色胺拮抗剂和抗血小板剂，更具体地说，是一种5-羟色胺拮抗剂和抗血小板剂，其具有强效和特异性地抑制5-羟色胺2受体的能力，并且副作用较低。
• Piperidine derivates and anti-platelet agents containing the same
  申请人：Ajinomoto Co., Inc.

  公开号：EP0682015A1

  公开（公告）日：1995-11-15

  Piperidine derivatives of general formula (I) or pharmaceutically acceptable salts thereof are useful in the manufacture of a medicament for use as a serotonin antagonist: wherein A¹ represents an unsubstituted or substituted pyridyl, piperidyl, piperidino, morpholinyl, morpholino, thiomorpholinyl, thiomorpholino or piperazinyl group, a substituted alkyl group having from 1 to 8 carbon atoms, a substituted cycloalkyl group having from 4 to 8 carbon atoms, or an unsubstituted or substituted alkoxyl group having 1 to 8 carbon atoms, X¹ represents a hydrogen atom or a halogen atom, Y¹ represents one of the organic groups: -CONH-, -NHCO-, -CONHCH₂-, -(CH₂)n-, -COO-, wherein n is an integer of from 0 to 4, and Z¹ represents one of the organic groups: -CH=CH-, -S-CH₂-, -S-, -CH₂-CH₂-.

  通式(I)的哌啶衍生物或其药学上可接受的盐类可用于制造作为血清素拮抗剂的药物： 其中 A¹ 代表未取代或取代的吡啶基、哌啶基、哌啶基、吗啉基、吗啉基、硫代吗啉基、硫代吗啉基或哌嗪基、具有 1 至 8 个碳原子的取代烷基、具有 4 至 8 个碳原子的取代环烷基或具有 1 至 8 个碳原子的未取代或取代烷氧基、 X¹ 代表氢原子或卤素原子、 Y¹ 代表以下有机基团之一 -CONH-、-NHCO-、-CONHCH₂-、-(CH₂)n-、-COO-、 其中 n 为 0 至 4 的整数，且 Z¹ 代表以下有机基团之一 -ch=ch-、-s-ch₂-、-s-、-ch₂-ch₂-。
• Piperidine derivatives and antiplatelet agents containing the same
  申请人：Ajinomoto Co., Inc.

  公开号：EP1103544A2

  公开（公告）日：2001-05-30

  Use of a piperidine derivative of general formula (I) or of a pharmaceutically acceptable salt thereof in the manufacture of a medicament for use as a 5HT2 antagonist in the treatment of ischaemic disorder, thrombosis, obstruction, arteriosclerosis, migraine or microcirculation failure, or for anti-platelet treatment: wherein A1 represents an unsubstituted or substituted pyridyl, piperidyl, piperidino, morpholinyl, morpholino, thiomorpholinyl, thiomorpholino or piperazinyl group, a substituted alkyl group having 1 to 8 carbon atoms, a substituted cycloalkyl group having from 4 to 8 carbon atoms, or an unsubstituted or substituted alkoxy group having 1 to 8 carbon atoms, X1 represents a hydrogen atom or a halogen atom, Y1 represents one of the organic groups:         -CONH-, -NHCO-, -CONHCH2-, -(CH2)n-, -COO-, wherein n is an integer of from 0 to 4, and Z1 represents one of the organic groups:         -CH=CH-, -S-CH2-, -S-, -CH2-CH2-.

  通式(I)的哌啶衍生物或其药学上可接受的盐在制造治疗缺血性疾病、血栓形成、阻塞、动脉硬化、偏头痛或微循环衰竭的5HT2拮抗剂或抗血小板治疗药物中的用途： 其中 A1 代表未取代或取代的吡啶基、哌啶基、哌啶基、吗啉基、吗啉基、 硫代吗啉基、硫代吗啉基或哌嗪基、具有 1 至 8 个碳原子的取代烷基、具有 4 至 8 个碳原子的取代环烷基或具有 1 至 8 个碳原子的未取代或取代烷氧基、 X1 代表氢原子或卤素原子、 Y1 代表有机基团之一： -CONH-、-NHCO-、-CONHCH2-、-(CH2)n-、-COO-、 其中 n 为 0 至 4 的整数，以及 Z1 代表有机基团之一： -ch=ch-、-s-ch2-、-s-、-ch2-ch2-。