(R)-3-(4-{2-[3-(2,4-dimethoxy-phenyl)-1-heptyl-ureido]-ethyl}-phenyl)-2-ethoxy-propionic acid

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: (R)-3-(4-{2-[3-(2,4-dimethoxy-phenyl)-1-heptyl-ureido]-ethyl}-phenyl)-2-ethoxy-propionic acid
• 英文别名: (2R)-3-[4-[2-[(2,4-dimethoxyphenyl)carbamoyl-heptylamino]ethyl]phenyl]-2-ethoxypropanoic acid
• 化学式: C₂₉H₄₂N₂O₆
• 分子量: 514.662
• InChiKey: ZNIDZJXFVCCDBG-HHHXNRCGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  37
• 可旋转键数：
  17
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  97.3
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• PPAR agonists
  申请人：——

  公开号：US20020165282A1

  公开（公告）日：2002-11-07

  PPAR alpha activators, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases, in mammals, including humans.

  PPAR alpha激动剂，含有这类化合物的药物组合物以及使用这类化合物提高特定血浆脂质水平，包括高密度脂蛋白胆固醇，并降低其他特定血浆脂质水平，如低密度脂蛋白胆固醇和甘油三酯，并据此治疗由高密度脂蛋白胆固醇水平低和/或低密度脂蛋白胆固醇和甘油三酯水平高加重的疾病，如动脉粥样硬化和心血管疾病，在哺乳动物，包括人类中的应用。
• PPAR AGONISTS
  申请人：Pfizer Products Inc.

  公开号：EP1360172A1

  公开（公告）日：2003-11-12
• US6699904B2
  申请人：——

  公开号：US6699904B2

  公开（公告）日：2004-03-02
• [EN] PPAR AGONISTS<br/>[FR] AGONISTES DES PPAR
  申请人：PFIZER PROD INC

  公开号：WO2002064549A1

  公开（公告）日：2002-08-22

  PPAR alpha activators, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certan plasma lipid levels, including high density liporprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases, in mammals, including humans.