8-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-7,8-dihydro-3H-6,9-dioxa-2,3-diaza-cyclopenta[a]naphthalene

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 8-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-7,8-dihydro-3H-6,9-dioxa-2,3-diaza-cyclopenta[a]naphthalene
• 英文别名: 2-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-3,7-dihydro-2H-[1,4]dioxino[2,3-e]indazole
• 化学式: C₁₉H₁₉N₃O₂
• 分子量: 321.379
• InChiKey: AMISUHAVKDMGOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  50.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  四氢异喹啉 、 isopropanolic HCl 、 (2R)-2,3-dihydro-7H-[1,4]dioxino[2,3-e]indazol-2-ylmethyl 4-methylbenzene-sulfonate 生成 8-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-7,8-dihydro-3H-6,9-dioxa-2,3-diaza-cyclopenta[a]naphthalene
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-2,3-diaza-cyclopenta[a]naphthalene
  申请人：Wyeth

  公开号：US20020183331A1

  公开（公告）日：2002-12-05

  Compounds of the formula: 1 useful for treatment of disorders of the dopaminergic system, such as schizophrenia, schizoaffective disorder, bipolar disorder, Parkinson's disease, L-DOPA induced pychoses and dyskinesias, Tourette's syndrome and hyperprolactinemia and in the treatment of drug addiction such as the addiction to ethanol, nicotine or cocaine and related illnesses.

  公式为1的化合物可用于治疗多巴胺系统的疾病，如精神分裂症、情感性精神障碍、双相情感障碍、帕金森病、L-DOPA诱发的精神病和运动障碍、抽动症和高泌乳素血症，以及治疗药物成瘾，如对乙醇、尼古丁或可卡因的成瘾及相关疾病。
• US6800641B2
  申请人：——

  公开号：US6800641B2

  公开（公告）日：2004-10-05
• [EN] ANTIPSYCHOTIC AMINOMETHYL DERIVATIVES OF 7,8-DIHYDRO-3H-6,9-DIOXA-2,3-DIAZA-CYCLOPENTA[a]NAPHTHALENE<br/>[FR] DERIVES ANTIPSYCHOTIQUES D'AMINOMETHYLE DE 7,8-DIHYDRO-3H-6,9-DIOXA-2,3-DIAZA-CYCLOPENTA[A]NAPHTHALENE
  申请人：WYETH CORP

  公开号：WO2002088133A1

  公开（公告）日：2002-11-07

  Compounds of the formula: useful for treatment of disorders of the dopaminergic system, such as schizophrenia, schizoaffective disorder, bipolar disorder, Parkinson's disease, L-DOPA induced psychoses and dyskinesias, Tourette's syndrome and hyperprolactinemia and in the treatment of drug addiction such as the addiction to ethanol, nicotine or cocaine and related illnesses.